This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-2 Monoclonal Antibody (JES6-5H4), PerCP-Cyanine5.5, eBioscience
catalog :
45-7021-82
quantity :
100 ug
price :
US 408.00
clonality :
monoclonal
host :
rat
conjugate :
PerCP/Cy5.5
reactivity :
mouse
application :
flow cytometry
citations: 130
Reference
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Roupie V, Pidot S, Einarsdottir T, Van Den Poel C, Jurion F, Stinear T, et al. Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice. PLoS Negl Trop Dis. 2014;8:e2604 pubmed publisher
Mollo S, Ingram J, Kress R, Zajac A, Harrington L. Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors. J Leukoc Biol. 2014;95:705-713 pubmed
Mollo S, Zajac A, Harrington L. Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol. 2013;191:6052-9 pubmed publisher
Friend S, Peterson L, Treacy E, Stefanski A, Sosinowski T, Pennock N, et al. The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation. PLoS ONE. 2013;8:e75200 pubmed publisher
Cooney L, Gupta M, Thomas S, Mikolajczak S, Choi K, Gibson C, et al. Short-lived effector CD8 T cells induced by genetically attenuated malaria parasite vaccination express CD11c. Infect Immun. 2013;81:4171-81 pubmed publisher
Baldwin S, Ching L, Pine S, Moutaftsi M, Lucas E, Vallur A, et al. Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells. J Immunol. 2013;191:2514-2525 pubmed publisher
Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K, et al. Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis. J Immunol. 2013;191:1073-81 pubmed publisher
Hu Z, Zhang W, Usherwood E. Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect. J Immunol. 2013;191:312-22 pubmed publisher
Jeon C, Kang S, Park S, Lim K, Hwang K, Min H. T Cell Stimulatory Effects of Korean Red Ginseng through Modulation of Myeloid-Derived Suppressor Cells. J Ginseng Res. 2011;35:462-70 pubmed publisher
Manzke N, Akhmetzyanova I, Hasenkrug K, Trilling M, Zelinskyy G, Dittmer U. CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells. J Virol. 2013;87:6306-13 pubmed publisher
Kwon H, Kim G, Kim Y, Hwang W, Jash A, Sahoo A, et al. Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clin Immunol. 2013;146:217-27 pubmed publisher
Kidder D, Richards H, Ziltener H, Garden O, Crocker P. Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. J Immunol. 2013;190:2593-602 pubmed publisher
Zhu M, Nagavalli A, Su M. Aire deficiency promotes TRP-1-specific immune rejection of melanoma. Cancer Res. 2013;73:2104-16 pubmed publisher
Condotta S, Rai D, James B, Griffith T, Badovinac V. Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection. J Immunol. 2013;190:1991-2000 pubmed publisher
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Baine I, Basu S, Ames R, Sellers R, Macian F. Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J Immunol. 2013;190:1008-16 pubmed publisher
Smithey M, Li G, Venturi V, Davenport M, Nikolich Zugich J. Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life. J Immunol. 2012;189:5356-66 pubmed publisher
Koga T, Ichinose K, Mizui M, Crispin J, Tsokos G. Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus. J Immunol. 2012;189:3490-6 pubmed
Jin J, Han X, Yu Q. Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation. J Autoimmun. 2013;40:28-44 pubmed publisher
Antvorskov J, Fundova P, Buschard K, Funda D. Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice. Immunology. 2013;138:23-33 pubmed publisher
Qi Y, Operario D, Georas S, Mosmann T. The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin. PLoS ONE. 2012;7:e39072 pubmed publisher
Kosinska A, Johrden L, Zhang E, Fiedler M, Mayer A, Wildner O, et al. DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model. J Virol. 2012;86:9297-310 pubmed publisher
Pham N, Badovinac V, Harty J. Epitope specificity of memory CD8+ T cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice. Eur J Immunol. 2012;42:1488-99 pubmed publisher
Carrier Y, Whitters M, Miyashiro J, LaBranche T, Ramon H, Benoit S, et al. Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. Eur J Immunol. 2012;42:1393-404 pubmed publisher
Lischke T, Hegemann A, Gurka S, Vu Van D, Burmeister Y, Lam K, et al. Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS. J Immunol. 2012;189:234-44 pubmed publisher
Garidou L, Heydari S, Gossa S, McGavern D. Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection. J Virol. 2012;86:7060-71 pubmed publisher
Yurchenko E, Shio M, Huang T, Da Silva Martins M, Szyf M, Levings M, et al. Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS ONE. 2012;7:e35572 pubmed publisher
Alari Pahissa E, Vega Ramos J, Zhang J, Castaño A, Turley S, Villadangos J, et al. Differential effect of CD69 targeting on bystander and antigen-specific T cell proliferation. J Leukoc Biol. 2012;92:145-58 pubmed publisher
Jiang X, Clark R, Liu L, Wagers A, Fuhlbrigge R, Kupper T. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012;483:227-31 pubmed publisher
Gottschalk R, Hathorn M, Beuneu H, Corse E, Dustin M, Altan Bonnet G, et al. Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Proc Natl Acad Sci U S A. 2012;109:881-6 pubmed publisher
George J, Eo S. Distinct Humoral and Cellular Immunity Induced by Alternating Prime-boost Vaccination Using Plasmid DNA and Live Viral Vector Vaccines Expressing the E Protein of Dengue Virus Type 2. Immune Netw. 2011;11:268-80 pubmed publisher
Nakano H, Free M, Whitehead G, Maruoka S, Wilson R, Nakano K, et al. Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol. 2012;5:53-65 pubmed publisher
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Yurchenko E, Levings M, Piccirillo C. CD4+ Foxp3+ regulatory T cells suppress ?? T-cell effector functions in a model of T-cell-induced mucosal inflammation. Eur J Immunol. 2011;41:3455-66 pubmed publisher
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Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch D, Belkaid Y, et al. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol. 2011;187:3186-97 pubmed publisher
Rausch M, Hastings K. GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1. J Invest Dermatol. 2012;132:154-62 pubmed publisher
Ganesh B, Bhattacharya P, Gopisetty A, Sheng J, Vasu C, Prabhakar B. IL-1? promotes TGF-?1 and IL-2 dependent Foxp3 expression in regulatory T cells. PLoS ONE. 2011;6:e21949 pubmed publisher
Wojno E, Hosken N, Stumhofer J, O Hara A, Mauldin E, Fang Q, et al. A role for IL-27 in limiting T regulatory cell populations. J Immunol. 2011;187:266-73 pubmed publisher
Weinger J, Brosnan C, Loudig O, Goldberg M, Macian F, Arnett H, et al. Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis. J Neuroinflammation. 2011;8:49 pubmed publisher
Chen Q, Kim Y, Laurence A, Punkosdy G, Shevach E. IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol. 2011;186:6329-37 pubmed publisher
Tosiek M, Gruber A, Bader S, Mauel S, Hoymann H, Prettin S, et al. CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation. J Immunol. 2011;186:6106-18 pubmed publisher
Rudolph M, Hebel K, Miyamura Y, Maverakis E, Brunner Weinzierl M. Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo. J Immunol. 2011;186:5580-9 pubmed publisher
Berretta F, St Pierre J, Piccirillo C, Stevenson M. IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection. J Immunol. 2011;186:4862-71 pubmed publisher
Yu Q, Sharma A, Ghosh A, Sen J. T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis. J Immunol. 2011;186:3946-52 pubmed publisher
Ruckstuhl T, Winterflood C, Seeger S. Supercritical angle fluorescence immunoassay platform. Anal Chem. 2011;83:2345-50 pubmed publisher
Lahl K, Sparwasser T. In vivo depletion of FoxP3+ Tregs using the DEREG mouse model. Methods Mol Biol. 2011;707:157-72 pubmed publisher
Srivastava R, Tomar G, Barhanpurkar A, Gupta N, Pote S, Mishra G, et al. IL-3 attenuates collagen-induced arthritis by modulating the development of Foxp3+ regulatory T cells. J Immunol. 2011;186:2262-72 pubmed publisher
Gibbert K, Dietze K, Zelinskyy G, Lang K, Barchet W, Kirschning C, et al. Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease. J Immunol. 2010;185:6179-89 pubmed publisher
Lee L, Baban D, Ronan E, Ragoussis J, Beverley P, Tchilian E. Chemokine gene expression in lung CD8 T cells correlates with protective immunity in mice immunized intra-nasally with Adenovirus-85A. BMC Med Genomics. 2010;3:46 pubmed publisher
Kastner L, Dwyer D, Qin F. Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells. J Immunol. 2010;185:5778-86 pubmed publisher
Yi J, Ingram J, Zajac A. IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol. 2010;185:4835-45 pubmed publisher
Jones G, Stumhofer J, Foster T, Twohig J, Hertzog P, Topley N, et al. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J. 2011;25:409-19 pubmed publisher
Weber K, Hildner K, Murphy K, Allen P. Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. J Immunol. 2010;185:2836-46 pubmed publisher
Darrah P, Hegde S, Patel D, Lindsay R, Chen L, Roederer M, et al. IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform. J Exp Med. 2010;207:1421-33 pubmed publisher
Bhadra R, Guan H, Khan I. Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondii. PLoS ONE. 2010;5:e10842 pubmed publisher
Nasreen M, Waldie T, Dixon C, Steptoe R. Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses. Eur J Immunol. 2010;40:2016-25 pubmed publisher
Olson J, Leveson Gower D, Gill S, Baker J, Beilhack A, Negrin R. NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects. Blood. 2010;115:4293-301 pubmed publisher
Day T, Koch M, Nouailles G, Jacobsen M, Kosmiadi G, Miekley D, et al. Secondary lymphoid organs are dispensable for the development of T-cell-mediated immunity during tuberculosis. Eur J Immunol. 2010;40:1663-73 pubmed publisher
Besche V, Wiechmann N, Castor T, Trojandt S, Höhn Y, Kunkel H, et al. Dendritic cells lentivirally engineered to overexpress interleukin-10 inhibit contact hypersensitivity responses, despite their partial activation induced by transduction-associated physical stress. J Gene Med. 2010;12:231-43 pubmed publisher
Tan A, Lam K. Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation. J Immunol. 2010;184:1849-57 pubmed publisher
Sonnenberg G, Mangan P, Bezman N, Sekiguchi D, Luning Prak E, Erikson J, et al. Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production. Blood. 2010;115:2186-95 pubmed publisher
Francisco L, Salinas V, Brown K, Vanguri V, Freeman G, Kuchroo V, et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009;206:3015-29 pubmed publisher
Massilamany C, Steffen D, Reddy J. An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice. J Neuroimmunol. 2010;219:17-24 pubmed publisher
Kim S, Han Y, Rahman M, Kim S, Yoo D, Kang S, et al. Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with beta2-adrenergic agonist. Exp Mol Med. 2009;41:812-23 pubmed publisher
Myers L, Messer R, Carmody A, Hasenkrug K. Tissue-specific abundance of regulatory T cells correlates with CD8+ T cell dysfunction and chronic retrovirus loads. J Immunol. 2009;183:1636-43 pubmed publisher
Garidou L, Heydari S, Truong P, Brooks D, McGavern D. Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection. J Virol. 2009;83:8905-15 pubmed publisher
Gatzka M, Newton R, Walsh C. Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development. J Immunol. 2009;183:285-97 pubmed publisher
Lee S, Salek Ardakani S, Mittler R, Croft M. Hypercostimulation through 4-1BB distorts homeostasis of immune cells. J Immunol. 2009;182:6753-62 pubmed publisher
Du G, Jin L, Han X, Song Z, Zhang H, Liang W. Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis. Cancer Res. 2009;69:3205-12 pubmed publisher
Makaroff L, Hendricks D, Niec R, Fink P. Postthymic maturation influences the CD8 T cell response to antigen. Proc Natl Acad Sci U S A. 2009;106:4799-804 pubmed publisher
Hamada H, Garcia Hernandez M, Reome J, Misra S, Strutt T, McKinstry K, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469-81 pubmed publisher
Kastenmuller W, Gasteiger G, Stross L, Busch D, Drexler I. Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens. J Immunol. 2009;182:2573-7 pubmed publisher
Fujisawa Y, Nabekura T, Nakao T, Nakamura Y, Takahashi T, Kawachi Y, et al. The induction of tumor-specific CD4+ T cells via major histocompatibility complex class II is required to gain optimal anti-tumor immunity against B16 melanoma cell line in tumor immunotherapy using dendritic cells. Exp Dermatol. 2009;18:396-403 pubmed publisher
Ramos S, Hernandez J, Gatzka M, Walsh C. Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity. J Immunol. 2008;181:7606-16 pubmed
Ing R, Stevenson M. Dendritic cell and NK cell reciprocal cross talk promotes gamma interferon-dependent immunity to blood-stage Plasmodium chabaudi AS infection in mice. Infect Immun. 2009;77:770-82 pubmed publisher
Sgouroudis E, Albanese A, Piccirillo C. Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J Immunol. 2008;181:6283-92 pubmed
Han Y, Aleyas A, George J, Kim S, Kim H, Yoo D, et al. Genetic co-transfer of CCR7 ligands enhances immunity and prolongs survival against virulent challenge of pseudorabies virus. Immunol Cell Biol. 2009;87:91-9 pubmed publisher
Liston A, Lu L, O Carroll D, Tarakhovsky A, Rudensky A. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med. 2008;205:1993-2004 pubmed publisher
Guo F, Iclozan C, Suh W, Anasetti C, Yu X. CD28 controls differentiation of regulatory T cells from naive CD4 T cells. J Immunol. 2008;181:2285-91 pubmed
Ito H, Ando K, Ishikawa T, Nakayama T, Taniguchi M, Saito K, et al. Role of Valpha14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of Valpha14+ NKT cells promotes the breakage of CTL tolerance. Int Immunol. 2008;20:869-79 pubmed publisher
Sridhar S, Reyes Sandoval A, Draper S, Moore A, Gilbert S, Gao G, et al. Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A. J Virol. 2008;82:3822-33 pubmed publisher
Jin R, Wang W, Yao J, Zhou Y, Qian X, Zhang J, et al. Characterization of the in vivo dynamics of medullary CD4+CD8- thymocyte development. J Immunol. 2008;180:2256-63 pubmed
Ahonen C, Wasiuk A, Fuse S, Turk M, Ernstoff M, Suriawinata A, et al. Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood. 2008;111:3116-25 pubmed publisher
Tritt M, Sgouroudis E, d Hennezel E, Albanese A, Piccirillo C. Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes. 2008;57:113-23 pubmed
Couper K, Blount D, Hafalla J, Van Rooijen N, de Souza J, Riley E. Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia. Infect Immun. 2007;75:5806-18 pubmed
Park S, Han Y, Aleyas A, George J, Yoon H, Lee J, et al. Low-dose antigen-experienced CD4+ T cells display reduced clonal expansion but facilitate an effective memory pool in response to secondary exposure. Immunology. 2008;123:426-37 pubmed
Nabekura T, Nagasawa T, Nakauchi H, Onodera M. An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2. Cancer Immunol Immunother. 2008;57:611-22 pubmed
Marshall N, Oda S, London C, Moulton H, Iversen P, Kerkvliet N, et al. Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing. J Immunol Methods. 2007;325:114-26 pubmed
Whitmire J, Eam B, Benning N, Whitton J. Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory. J Immunol. 2007;179:1190-7 pubmed
Denkinger C, Denkinger M, Forsthuber T. Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation. Cell Immunol. 2007;246:46-54 pubmed
Badovinac V, Harty J. Manipulating the rate of memory CD8+ T cell generation after acute infection. J Immunol. 2007;179:53-63 pubmed
Sather B, Treuting P, Perdue N, Miazgowicz M, Fontenot J, Rudensky A, et al. Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med. 2007;204:1335-47 pubmed
Kroenke M, Segal B. Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis. J Neurosci Res. 2007;85:1685-93 pubmed
Hernandez M, Shen L, Rock K. CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help. J Immunol. 2007;178:2844-52 pubmed
Zheng S, Wang J, Wang P, Gray J, Horwitz D. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol. 2007;178:2018-27 pubmed
Wu W, Weigand L, Belkaid Y, Mendez S. Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides. Eur J Immunol. 2006;36:3238-47 pubmed
Kobie J, Shah P, Yang L, Rebhahn J, Fowell D, Mosmann T. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol. 2006;177:6780-6 pubmed
Gadola S, Silk J, Jeans A, Illarionov P, Salio M, Besra G, et al. Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases. J Exp Med. 2006;203:2293-303 pubmed
Haring J, Harty J. Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor. Infect Immun. 2006;74:6252-63 pubmed
Luke P, Deng J, Lian D, O Connell P, Garcia B, Jevnikar A, et al. Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi: CD45RBlo T-cell proportions. Am J Transplant. 2006;6:2023-34 pubmed
Badovinac V, Messingham K, Griffith T, Harty J. TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells. J Immunol. 2006;177:999-1006 pubmed
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product information
Product Type :
Antibody
Product Name :
IL-2 Monoclonal Antibody (JES6-5H4), PerCP-Cyanine5.5, eBioscience
Catalog # :
45-7021-82
Quantity :
100 ug
Price :
US 408.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 ug/test
Species :
Mouse
Clone :
JES6-5H4
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 ug/test
Aliases :
aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA