PDHA1 Monoclonal Antibody (8D10E6) | Invitrogen 45-6600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PDHA1 Monoclonal Antibody (8D10E6)

catalog :

45-6600

quantity :

100 µg

price :

US 402.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8D10E6

reactivity :

human, mouse, rat, bovine, zebrafish

application :

western blot, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:750; fig 2	Miquel E, Cassina A, Martinez Palma L, Bolatto C, Trias E, Gandelman M, et al. Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis. PLoS ONE. 2012;7:e34776 pubmed publisher
	Valuparampil Varghese M, James J, Eccles C, Niihori M, Rafikova O, Rafikov R. Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension. J Clin Med. 2020;9: pubmed publisher
	Varghese M, Niihori M, Eccles C, Kurdyukov S, James J, Rafikova O, et al. Antioxidant-Conjugated Peptide Attenuated Metabolic Reprogramming in Pulmonary Hypertension. Antioxidants (Basel). 2020;9: pubmed publisher
	Pareek G, Thomas R, Vincow E, Morris D, Pallanck L. Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation. Cell Death Discov. 2018;4:51 pubmed publisher
	Bas Orth C, Tan Y, Lau D, Bading H. Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect. J Biol Chem. 2017;292:5183-5194 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PDHA1 Monoclonal Antibody (8D10E6)

Catalog # :

45-6600

Quantity :

100 µg

Price :

US 402.00

Clonality :

Monoclonal

Purity :

IgG fraction

Host :

Mouse

Reactivity :

Bovine, Drosophila, Human, Mouse, Rat, Zebrafish

Applications :

Flow Cytometry: 1 µg/mL, Immunocytochemistry: 1 µg/mL, Western Blot: 0.5-1.0 µg/mL

Species :

Bovine, Drosophila, Human, Mouse, Rat, Zebrafish

Clone :

8D10E6

Isotype :

IgG1, kappa

Storage :

4° C, do not freeze

Description :

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen :

Human recombinant PDH-E1-alpha

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/mL, Immunocytochemistry: 1 µg/mL, Western Blot: 0.5-1.0 µg/mL

Aliases :

PDHA; PDHA1; Pdha-1; PDHAD; PDHCE1A; PDHE1-A type I; PHE1A; pyruvate dehydrogenase; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase complex, E1-alpha polypeptide 1; pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component alpha subunit; pyruvate dehydrogenase E1 component alpha subunit precursor; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1 subunit; pyruvate dehydrogenase E1 subunit alpha 1; pyruvate dehydrogenase E1alpha subunit

more info or order :

Invitrogen product webpage