Phospho-PKC epsilon (Ser729) Polyclonal Antibody | Invitrogen 44-977G product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PKC epsilon (Ser729) Polyclonal Antibody

catalog :

44-977G

quantity :

100 uL

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse

application :

western blot

citations: 2

Reference
La Cognata V, D Amico A, Maugeri G, Morello G, Guarnaccia M, Magr xec B, et al. The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating SOD1-G93A Motor Neuron-like Cells. Int J Mol Sci. 2023;24: pubmed publisher
Martini S, Davis K, Faraway R, Elze L, Lockwood N, Jones A, et al. A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division. Nat Commun. 2021;12:6934 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-PKC epsilon (Ser729) Polyclonal Antibody

Catalog # :

44-977G

Quantity :

100 uL

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: 1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C

Description :

The PKC family of serine/threonine kinases, including PRKCE (PKC epsilon), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human PKCe that contains serine 729. The sequence is conserved in mouse and rat.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

5830406C15Rik; MGC125656; MGC125657; nPKC-epsilon; PKC e; PKC[e]; Pkce; Pkcea; PKCepsilon; PRKCE; PRKCH; protein kinase C; protein kinase C epsilon; protein kinase C epsilon type; protein kinase C, epsilon; protein kinase C, eta; R75156