Phospho-PAK1/2/3 (Ser141) Polyclonal Antibody | Invitrogen 44-940G product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PAK1/2/3 (Ser141) Polyclonal Antibody

catalog :

44-940G

quantity :

100 µL

price :

US 430.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

African green monkey, human

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig st1	Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
immunocytochemistry; African green monkey; 1:150; fig s8	Reinhard J, Kriz A, Galic M, Angliker N, Rajalu M, Vogt K, et al. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun. 2016;7:11613 pubmed publisher
	Yamahashi Y, Lin Y, Mouri A, Iwanaga S, Kawashima K, Tokumoto Y, et al. Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning. Mol Psychiatry. 2022;27:3479-3492 pubmed publisher
	Banka S, Bennington A, Baker M, Rijckmans E, Clemente G, Ansor N, et al. Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology. Brain. 2022;145:4232-4245 pubmed publisher
	Alfaidi M, Bhattarai U, Orr A. Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability. J Am Heart Assoc. 2020;9:e016099 pubmed publisher
	Yang C, Yu T, Wen W, Ling P, Hsu K. Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation. J Neurosci. 2019;39:4959-4975 pubmed publisher
	Chow H, Dong B, Valencia C, Zeng C, Koch J, Prudnikova T, et al. Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer. Nat Commun. 2018;9:3473 pubmed publisher
	Bories C, Arsenault D, Lemire M, Tremblay C, De Koninck Y, Calon F. Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease. Aging (Albany NY). 2017;9:1386-1403 pubmed publisher
	Cui S, Zhang K, Li C, Chen J, Pan Y, Feng B, et al. Methylation-associated silencing of microRNA-129-3p promotes epithelial-mesenchymal transition, invasion and metastasis of hepatocelluar cancer by targeting Aurora-A. Oncotarget. 2016;7:78009-78028 pubmed publisher
	Hahn C, Scott D, Xu X, Roda M, Payne G, Wells J, et al. The matrikine N-Î±-PGP couples extracellular matrix fragmentation to endothelial permeability. Sci Adv. 2015;1: pubmed
	Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed

product information

Product Type :

Antibody

Product Name :

Phospho-PAK1/2/3 (Ser141) Polyclonal Antibody

Catalog # :

44-940G

Quantity :

100 µL

Price :

US 430.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 1:1,000

Species :

Human

Isotype :

IgG

Storage :

-20°C

Description :

In mammals, there are several identified isoforms of p21-Activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated wit X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003; Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).

Immunogen :

Synthetic phosphopeptide derived from a region of human PAK2 containing serine 141. The sequence is conserved in rat and rabbit.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

5330420P17Rik; A130002K10Rik; activated protein kinase alpha; ADRB2; adriamycin resistance-associated; AI836325; Alpha-PAK; ARA; AW045634; Beta-PAK; bPAK; CDC42/RAC effector kinase PAK-A; CDC42/RAC effector kinase PAK-B; CDKN1A; C-t-PAK2; D16Ertd269e; EC 2.7.11.1; gamma pak; gamma-PAK; hPAK3; kinase PAK1; mKIAA4182; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 1; p21 (CDKN1A)-activated kinase 2; p21 (CDKN1A)-activated kinase 3; p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 (RAC1) activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21-activated kinase 1; p21-activated kinase 2; p21-activated kinase 3; p27; p34; p58; p65-PAK; p68-PAK; PAK 1; PAK alpha; PAK beta; PAK gamma; Pak1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK3beta; PAK65; Pak65alpha; Pak65beta; Paka; PAKalpha; Pakb; PAKgamma; Protein kinase MUK2; S6/H4 kinase; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; STE20 homolog, yeast; Stk4

more info or order :

Invitrogen product webpage