This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-IRS1 (Tyr941) Polyclonal Antibody
catalog :
44-820G
quantity :
10 blots
price :
US 341
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse
application :
western blot
product information
Product Type :
Antibody
Product Name :
Phospho-IRS1 (Tyr941) Polyclonal Antibody
Catalog # :
44-820G
Quantity :
10 blots
Price :
US 341
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
Western Blot: 1:1000
Species :
Human, Mouse
Isotype :
IgG
Storage :
-20°C
Description :
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm’s tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic option. To date there have been four subtypes identified: IRS-1,2,3, and 4, with IRS-1 being widely expressed.
Immunogen :
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of mouse IRS-1 that contains tyrosine 935 (tyrosine 941 in the human sequence). The sequence is conserved in rat.
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1:1000
Aliases :
IRS-1, IRS1, Insulin receptor substrate-1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA