| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; 1:1000; loading ...; fig 1a
| Valencia A, Bieber V, Bajrami B, Marsh G, Hamann S, Wei R, et al. Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice. Front Neurol. 2021;12:624051 pubmed publisher |
- western blot; human; loading ...; fig 4c
| Sonntag T, Moresco J, Yates J, Montminy M. The KLDpT activation loop motif is critical for MARK kinase activity. PLoS ONE. 2019;14:e0225727 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 8b
| Qu X, Yuan F, Corona C, Pasini S, Pero M, Gundersen G, et al. Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity. J Cell Biol. 2017;216:3161-3178 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 1d
- western blot; human; 1:1000; loading ...; fig s5b
| Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher |
- western blot; human; 1:1000; fig 1a
| Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed publisher |
- western blot; human; 1:2500; loading ...; fig 4a
| Sun W, Lee S, Huang X, Liu S, Inayathullah M, Kim K, et al. Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sci Rep. 2016;6:34784 pubmed publisher |
- western blot; mouse; loading ...; fig 6a
| Dinkins M, Enasko J, Hernandez C, Wang G, Kong J, Helwa I, et al. Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse. J Neurosci. 2016;36:8653-67 pubmed publisher |
- western blot; mouse; 1:1000; fig 3
| Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, et al. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016;15:914-23 pubmed publisher |
- western blot; rat
- immunohistochemistry - paraffin section; dogs; 1:1000
- western blot; mouse
| Smolek T, Madari A, Farbáková J, Kandrac O, Jadhav S, Cente M, et al. Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment. J Comp Neurol. 2016;524:874-95 pubmed publisher |
| Dridi H, Liu Y, Reiken S, Liu X, Argyrousi E, Yuan Q, et al. Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2. Nat Neurosci. 2023;26:1365-1378 pubmed publisher |
| Denechaud M, Geurs S, Comptdaer T, B xe9 gard S, Garcia N xfa xf1 ez A, Pechereau L, et al. Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease. Prog Neurobiol. 2023;223:102386 pubmed publisher |
| Kim Y, Siddiqui T, Blaze J, Cosacak M, Winters T, Kumar A, et al. RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation. Acta Neuropathol. 2023;145:29-48 pubmed publisher |
| Li L, Miao J, Chu D, Jin N, Tung Y, Dai C, et al. Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation. CNS Neurosci Ther. 2022;28:2245-2259 pubmed publisher |
| Tan B, Babür E, Toy N, G xfc nayd x131 n B, Dursun N, S xfc er C. Tau protein is differentially phosphorylated in young- and old-aged rats with experimentally induced hyperthyroidism. Int J Dev Neurosci. 2022;82:654-663 pubmed publisher |
| Brody A, Nies S, Guan F, Smith L, Mukherjee B, Salazar S, et al. Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. Mol Neurodegener. 2022;17:32 pubmed publisher |
| Tabassum Z, Tseng J, Isemann C, Tian X, Chen Y, Herring L, et al. Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase. J Biol Chem. 2022;298:101977 pubmed publisher |
| Sun Z, Hu J, Wu J, Zhou B, Huang Y. Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model. Neural Regen Res. 2022;17:2286-2292 pubmed publisher |
| Zhu X, Liu L, Dai W, Ma T. Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. Neural Regen Res. 2022;17:1841-1849 pubmed publisher |
| Hayne M, DiAntonio A. Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival. Neurobiol Dis. 2022;163:105586 pubmed publisher |
| Nie L, He K, Xie F, Xiao S, Li S, Xu J, et al. Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer's disease. Aging (Albany NY). 2021;13:23739-23756 pubmed publisher |
| Brigas H, Ribeiro M, Coelho J, Gomes R, Gomez Murcia V, Carvalho K, et al. IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease. Cell Rep. 2021;36:109574 pubmed publisher |
| Badawi G, Shokr M, Zaki H, Mohamed A. Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats. Clin Exp Pharmacol Physiol. 2021;48:1111-1124 pubmed publisher |
| McDaid J, Briggs C, Barrington N, Peterson D, Kozlowski D, Stutzmann G. Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts. Front Cell Neurosci. 2021;15:652721 pubmed publisher |
| Martinez Valbuena I, Valenti Azcarate R, Amat Villegas I, Marcilla I, Martí Andrés G, Caballero M, et al. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathol Commun. 2021;9:64 pubmed publisher |
| Reimer L, Betzer C, Kofoed R, Volbracht C, Fog K, Kurhade C, et al. PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation. Brain Pathol. 2021;31:103-119 pubmed publisher |
| Mankhong S, Kim S, Moon S, Lee K, Jeon H, Hwang B, et al. Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion. Int J Mol Sci. 2020;21: pubmed publisher |
| Gu J, Xu W, Jin N, Li L, Zhou Y, Chu D, et al. Truncation of Tau selectively facilitates its pathological activities. J Biol Chem. 2020;295:13812-13828 pubmed publisher |
| Dominguez Meijide A, Vasili E, König A, Cima Omori M, Ibañez de Opakua A, Leonov A, et al. Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Sci Rep. 2020;10:12827 pubmed publisher |
| Lee H, Jung Y, Choi G, Kim J, Chae C, Lim J, et al. Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis. Cell Death Differ. 2020;: pubmed publisher |
| Chen D, Mei Y, Kim N, Lan G, Gan C, Fan F, et al. Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease. J Pineal Res. 2020;69:e12665 pubmed publisher |
| Zimmermann H, Yang W, Kasica N, Zhou X, Wang X, Beckelman B, et al. Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice. J Clin Invest. 2020;130:3511-3527 pubmed publisher |
| Zappettini S, Faivre E, Ghestem A, Carrier S, Buee L, Blum D, et al. Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy. Front Cell Neurosci. 2019;13:438 pubmed publisher |
| Ko H, Chiou S, Wong Y, Wang Y, Lai Y, Chou C, et al. GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease. J Clin Med. 2019;8: pubmed publisher |
| Martinez Valbuena I, Valenti Azcarate R, Amat Villegas I, Riverol M, Marcilla I, de Andrea C, et al. Amylin as a potential link between type 2 diabetes and alzheimer disease. Ann Neurol. 2019;86:539-551 pubmed publisher |
| Miao J, Shi R, Li L, Chen F, Zhou Y, Tung Y, et al. Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo. Front Aging Neurosci. 2019;11:34 pubmed publisher |
| Zhang Y, Lv Y, Si Y, Zhou J, Qian Y, Bao H. α-lipoic acid attenuates spatial learning and memory impairment induced by hepatectomy. Exp Ther Med. 2019;17:2329-2333 pubmed publisher |
| Zhang Y, Wu F, Iqbal K, Gong C, Hu W, Liu F. Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice. Sci Rep. 2019;9:3789 pubmed publisher |
| Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, et al. Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex. Cereb Cortex. 2019;29:3738-3751 pubmed publisher |
| Liu P, Chen X, Zhou H, Wang L, Zhang Z, Ren X, et al. The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro. Oxid Med Cell Longev. 2018;2018:2025914 pubmed publisher |
| Borin M, Saraceno C, Catania M, Lorenzetto E, Pontelli V, Paterlini A, et al. Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease. Acta Neuropathol Commun. 2018;6:61 pubmed publisher |
| Hu W, Tung Y, Zhang Y, Liu F, Iqbal K. Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury. J Alzheimers Dis. 2018;64:709-722 pubmed publisher |
| Zuo C, Wang C, Liu J, Shen T, Zhou J, Hao X, et al. Isoflurane anesthesia in aged mice and effects of A1 adenosine receptors on cognitive impairment. CNS Neurosci Ther. 2018;24:212-221 pubmed publisher |
| Khan P, Rahman S, Queen A, Manzoor S, Naz F, Hasan G, et al. Elucidation of Dietary Polyphenolics as Potential Inhibitor of Microtubule Affinity Regulating Kinase 4: In silico and In vitro Studies. Sci Rep. 2017;7:9470 pubmed publisher |
| O Hare Doig R, Chiha W, Giacci M, Yates N, Bartlett C, Smith N, et al. Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma. BMC Neurosci. 2017;18:62 pubmed publisher |
| Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, et al. Tau deletion promotes brain insulin resistance. J Exp Med. 2017;214:2257-2269 pubmed publisher |
| Takeda S, Wegmann S, Cho H, DeVos S, Commins C, Roe A, et al. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015;6:8490 pubmed publisher |
