Phospho-PLCG1 (Tyr783) Polyclonal Antibody | Invitrogen 44-696G product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PLCG1 (Tyr783) Polyclonal Antibody

catalog :

44-696G

quantity :

100 µL

price :

US 466

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 3	Ksionda O, Melton A, Bache J, Tenhagen M, Bakker J, Harvey R, et al. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene. 2016;35:3658-68 pubmed publisher
	Choi S, Hatzihristidis T, Gaud G, Dutta A, Lee J, Arya A, et al. GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1. J Exp Med. 2023;220: pubmed publisher
	Nitzsche A, Pietilä R, Love D, Testini C, Ninchoji T, Smith R, et al. Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis. EMBO Rep. 2021;22:e50218 pubmed publisher
	Liu Y, Cai B, Chong Y, Zhang H, Kemp C, Lu S, et al. Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome. Cell Death Dis. 2020;11:884 pubmed publisher
	Lewis J, Scangarello F, Murphy J, Eidell K, Sodipo M, Ophir M, et al. ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters. J Cell Sci. 2018;131: pubmed publisher
	Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, et al. THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1. Nat Immunol. 2017;18:433-441 pubmed publisher
	Freedman T, Tan Y, Skrzypczynska K, Manz B, Sjaastad F, Goodridge H, et al. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. elife. 2015;4: pubmed publisher
	Manz B, Tan Y, Courtney A, Rutaganira F, Palmer E, Shokat K, et al. Small molecule inhibition of Csk alters affinity recognition by T cells. elife. 2015;4: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-PLCG1 (Tyr783) Polyclonal Antibody

Catalog # :

44-696G

Quantity :

100 µL

Price :

US 466

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20°C

Description :

The mammalian Phospholipase Cg (PLCg) family has two closely related proteins, PLCg1 and PLCg2. The PLCg isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCg. Activated PLCg catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PLC-gamma-1 that contains tyrosine 783. This region is conserved among many species including mouse, rat, cow and frog.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000

Aliases :

1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; AI894140; Cded; cell differentiation and embryonic development; EC 3.1.4.11; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; NCKAP3; OTTHUMP00000178982; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C gamma 1; phospholipase C, gamma 1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-1; phospholipase C-148; Phospholipase C2; phospholipase C-gamma-1; Phospholipase C-II; PLC gamma1; PLC1; Plc-1; PLC148; PLC-148; PLC2I; Plcg1; Plcg-1; PLCgamma1; Plc-gamma1; PLC-gamma-1; PLC-II; PPLCA; triphosphoinositide phosphodiesterase

more info or order :

Invitrogen product webpage