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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-JNK1/JNK2 (Thr183, Tyr185) Polyclonal Antibody
catalog :
44-682G
quantity :
100 µL
price :
US 514
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat, pigs
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
Invitrogen product webpage
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig e6j
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574:553-558 pubmed publisher
  • western blot; human; loading ...; fig 1c
Zhang J, MacArtney T, Peggie M, Cohen P. Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. Biochem J. 2017;474:2235-2248 pubmed publisher
  • western blot; pigs ; loading ...; fig 3a
  • western blot; mouse; loading ...; fig 3b
Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed publisher
  • western blot; mouse; 1:1000; fig s6
Fern ndez Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed publisher
  • western blot; mouse; loading ...; fig s9
Rackov G, Hernandez Jimenez E, Shokri R, Carmona Rodríguez L, Manes S, Alvarez Mon M, et al. p21 mediates macrophage reprogramming through regulation of p50-p50 NF-?B and IFN-?. J Clin Invest. 2016;126:3089-103 pubmed publisher
  • western blot; human; loading ...; fig 3b
Afonina I, Van Nuffel E, Baudelet G, Driege Y, Kreike M, Staal J, et al. The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes. EMBO Rep. 2016;17:914-27 pubmed publisher
  • western blot; mouse; fig 1
Ismail H, Miotla Zarebska J, Troeberg L, Tang X, Stott B, Yamamoto K, et al. Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis. Arthritis Rheumatol. 2016;68:1165-71 pubmed publisher
Sharlo K, Lvova I, Tyganov S, Sergeeva K, Kalashnikov V, Kalashnikova E, et al. A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression. Curr Issues Mol Biol. 2023;45:5613-5630 pubmed publisher
Lai P, Yen C, Lin M, Chen Y, Liao H, Huang Y, et al. Electroacupuncture Attenuates Fibromyalgia Pain via Toll-like Receptor 4 in the Mouse Brain. Life (Basel). 2023;13: pubmed publisher
Ciou H, Lee T, Wang H, Ding Y, Tseng C, Wang P, et al. Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer. Transl Res. 2022;243:21-32 pubmed publisher
Zhang Y, Wen X, Guo X, Huang S, Wang T, Zhou P, et al. Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway. Oncol Rep. 2021;45: pubmed publisher
Fang K, Kevil C. Caveolin-1 Scaffolding Domain Peptide Regulates Colon Endothelial Cell Survival through JNK Pathway. Int J Inflam. 2020;2020:6150942 pubmed publisher
van der Velden J, Alcorn J, Chapman D, Lundblad L, Irvin C, Davis R, et al. Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models. PLoS ONE. 2020;15:e0226904 pubmed publisher
Inprasit C, Huang Y, Lin Y. Evidence for acupoint catgut embedding treatment and TRPV1 gene deletion increasing weight control in murine model. Int J Mol Med. 2020;45:779-792 pubmed publisher
Souvannaseng L, Hun L, Baker H, Klyver J, Wang B, Pakpour N, et al. Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS Pathog. 2018;14:e1007418 pubmed publisher
Hwang J, Kim K, Park J, Kim S, Cho H, Lee Y, et al. Glucosamine improves survival in a mouse model of sepsis and attenuates sepsis-induced lung injury and inflammation. J Biol Chem. 2019;294:608-622 pubmed publisher
Hagiwara S, Kaushal E, Paruthiyil S, Pasricha P, Hasdemir B, Bhargava A. Gastric corticotropin-releasing factor influences mast cell infiltration in a rat model of functional dyspepsia. PLoS ONE. 2018;13:e0203704 pubmed publisher
Glennon E, Torrevillas B, Morrissey S, Ejercito J, Luckhart S. Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity. Parasit Vectors. 2017;10:333 pubmed publisher
Zheng S, Long L, Li Y, Xu Y, Jiqin Z, Ji W, et al. A Novel ASK Inhibitor AGI-1067 Inhibits TLR-4-Mediated Activation of ASK1 by Preventing Dissociation of Thioredoxin from ASK1. Cardiovasc Pharm Open Access. 2015;4: pubmed publisher
Hwang J, Kwon M, Kim K, Lee Y, Lyoo I, Kim J, et al. Lipopolysaccharide (LPS)-stimulated iNOS Induction Is Increased by Glucosamine under Normal Glucose Conditions but Is Inhibited by Glucosamine under High Glucose Conditions in Macrophage Cells. J Biol Chem. 2017;292:1724-1736 pubmed publisher
Xu Q, Choksi S, Qu J, Jang J, Choe M, Banfi B, et al. NADPH Oxidases Are Essential for Macrophage Differentiation. J Biol Chem. 2016;291:20030-41 pubmed publisher
Tan B, Mu R, Chang Y, Wang Y, Wu M, Tu H, et al. RNF4 negatively regulates NF-κB signaling by down-regulating TAB2. FEBS Lett. 2015;589:2850-8 pubmed publisher
Malik N, Vollmer S, Nanda S, López Pelaéz M, Prescott A, Gray N, et al. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members. Biochem J. 2015;468:363-72 pubmed publisher
Ismail H, Yamamoto K, Vincent T, Nagase H, Troeberg L, Saklatvala J. Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes. Arthritis Rheumatol. 2015;67:1826-36 pubmed publisher
Kim S, Kim W, Yoon J, Ji J, Morgan M, Cho H, et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis. J Invest Dermatol. 2015;135:2021-2030 pubmed publisher
Shi S, Wang Q, Xu J, Jang J, Padilla M, Nyunoya T, et al. Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Oncotarget. 2015;6:1640-51 pubmed
Park D, Lalli J, Sedlackova Slavikova L, Rice S. Functional comparison of herpes simplex virus 1 (HSV-1) and HSV-2 ICP27 homologs reveals a role for ICP27 in virion release. J Virol. 2015;89:2892-905 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Phospho-JNK1/JNK2 (Thr183, Tyr185) Polyclonal Antibody
Catalog # :
44-682G
Quantity :
100 µL
Price :
US 514
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 1:250, Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20°C
Description :
C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.
Immunogen :
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human JNK1&2 that contains threonine 183 and tyrosine 185. This region is conserved among many species including mouse, rat, chicken, nematode, fruit fly, and in JNK3.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:250, Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000
Aliases :
AI849689; AI851083; C-jun kinase; c-Jun kinase 2; c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 2; I79_012561; JNK; JNK 55; JNK/SAPK alpha; JNK1; JNK1 beta1 protein kinase; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK-46; JNK-55; Jun kinase; JUN N-terminal kinase; MAP kinase 8; MAP kinase 9; MAPK; MAPK 8; MAPK 9; Mapk8; Mapk9; mitogen activated protein kinase 8; mitogen activated protein kinase 9; mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 9; OTTHUMP00000019552; p54 gamma; p54a; p54-alpha; p54aSAPK; Phospho-JNK; PRKM; PRKM8; Prkm9; protein kinase JNK1; protein kinase mitogen-activated 8; protein kinase, mitogen-activated 9; SAPK; SAPK 1; SAPK gamma; SAPK1; SAPK1A; SAPK1c; SAPK-alpha; stress activated protein kinase alpha II; stress-activated protein kinase 1; stress-activated protein kinase 1a; Stress-activated protein kinase 1c; stress-activated protein kinase JNK1; Stress-activated protein kinase JNK2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA