Phospho-PYK2 (Tyr579, Tyr580) Polyclonal Antibody | Invitrogen 44-636G product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PYK2 (Tyr579, Tyr580) Polyclonal Antibody

catalog :

44-636G

quantity :

100 uL

price :

US 520.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 7

Reference
Ortiz Rivera J, Velez Crespo G, Inyushin M, KUCHERYAVYKH Y, Kucheryavykh L. Pyk2/FAK Signaling Is Upregulated in Recurrent Glioblastoma Tumors in a C57BL/6/GL261 Glioma Implantation Model. Int J Mol Sci. 2023;24: pubmed publisher
Liu M, Liu H, Feng F, Krook Magnuson E, Dudley S. TRPM7 kinase mediates hypomagnesemia-induced seizure-related death. Sci Rep. 2023;13:7855 pubmed publisher
Ortiz Rivera J, Nu xf1 ez R, KUCHERYAVYKH Y, Kucheryavykh L. The PYK2 inhibitor PF-562271 enhances the effect of temozolomide on tumor growth in a C57Bl/6-Gl261 mouse glioma model. J Neurooncol. 2023;161:593-604 pubmed publisher
Wilson A, Richards M, Curtis M, Gunadasa Rohling M, Monterisi S, Loonat A, et al. Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH. Cardiovasc Res. 2022;118:2946-2959 pubmed publisher
Nu xf1 ez R, Del Valle M, Ortiz K, Almodovar L, Kucheryavykh L. Microglial Cytokines Induce Invasiveness and Proliferation of Human Glioblastoma through Pyk2 and FAK Activation. Cancers (Basel). 2021;13: pubmed publisher
Loving H, Underbakke E. Conformational Dynamics of FERM-Mediated Autoinhibition in Pyk2 Tyrosine Kinase. Biochemistry. 2019;58:3767-3776 pubmed publisher
RolÃ³n Reyes K, Kucheryavykh Y, Cubano L, Inyushin M, Skatchkov S, Eaton M, et al. Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PLoS ONE. 2015;10:e0131059 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-PYK2 (Tyr579, Tyr580) Polyclonal Antibody

Catalog # :

44-636G

Quantity :

100 uL

Price :

US 520.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Pyk2 that contains tyrosines 579 and 580. The sequence is conserved in mouse and rat.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000

Aliases :

CADTK; CAK beta; CAKB; CAKbeta; CAK-beta; calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK; FADK 2; FADK2; FAK; FAK1; FAK2; focal adhesion kinase 2; FRNK; PKB; pp125FAK; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase