Phospho-PYK2 (Tyr580) Polyclonal Antibody | Invitrogen 44-634G product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PYK2 (Tyr580) Polyclonal Antibody

catalog :

44-634G

quantity :

10 blots

price :

US 309.00

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot, immunohistochemistry

citations: 4

Reference
Bernard Trifilo J, Lim S, Hou S, Schlaepfer D, Ilic D. Analyzing FAK and Pyk2 in early integrin signaling events. Curr Protoc Cell Biol. 2006;Chapter 14:Unit 14.7 pubmed publisher
Schindler E, Baumgartner M, Gribben E, Li L, Efimova T. The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes. J Invest Dermatol. 2007;127:1094-106 pubmed
Banno Y, Ohguchi K, Matsumoto N, Koda M, Ueda M, Hara A, et al. Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells. J Biol Chem. 2005;280:16319-24 pubmed
Wang Z, Brecher P. Salicylate Inhibits Phosphorylation of the Nonreceptor Tyrosine Kinases, Proline-Rich Tyrosine Kinase 2 and c-Src. Hypertension. 2001;37:148-153 pubmed

product information

Product Type :

Antibody

Product Name :

Phospho-PYK2 (Tyr580) Polyclonal Antibody

Catalog # :

44-634G

Quantity :

10 blots

Price :

US 309.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent

Species :

Human

Isotype :

IgG

Storage :

-20°C

Description :

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Pyk2 that contains tyrosine 580. The sequence is conserved in mouse and rat.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent

Aliases :

CADTK, CAKB, FADK2, PKB, PTK, PTK2B, RAFTK, Focal Adhesion Kinase 2