Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody | Invitrogen 44-426G product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody

catalog :

44-426G

quantity :

100 uL

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot

citations: 6

Reference
Li W, Fu X, Wang Z, Li Z, Ma D, Sun P, et al. Krüppel-like factor 7 attenuates hippocampal neuronal injury after traumatic brain injury. Neural Regen Res. 2022;17:661-672 pubmed publisher
Rashid M, Ali R, Almuzzaini B, Song H, Alhallaj A, Abdulkarim A, et al. Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer. Cancer Med. 2021;10:8138-8150 pubmed publisher
Elhennawy M, Abdelaleem E, Zaki A, Mohamed W. Cinnamaldehyde and hesperetin attenuate TNBS-induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway. J Biochem Mol Toxicol. 2021;35:e22730 pubmed publisher
Ferrer B, Prince L, Tinkov A, Santamaria A, Farina M, Rocha J, et al. Chronic exposure to methylmercury enhances the anorexigenic effects of leptin in C57BL/6J male mice. Food Chem Toxicol. 2021;147:111924 pubmed publisher
Moon P, Kim M, Oh H, Nam S, Han N, Jeong H, et al. Cysteine induces longitudinal bone growth in mice by upregulating IGF-I. Int J Mol Med. 2015;36:571-6 pubmed publisher
Jay J, Hammer A, Nestor Kalinoski A, Diakonova M. JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein. Mol Cell Biol. 2015;35:111-31 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody

Catalog # :

44-426G

Quantity :

100 uL

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of mouse JAK2 that contains tyrosines 1007 and 1008.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2