Phospho-STAT1 (Tyr701) Polyclonal Antibody | Invitrogen 44-376G product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-STAT1 (Tyr701) Polyclonal Antibody

catalog :

44-376G

quantity :

100 µL

price :

US 566

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, reverse phase protein lysate microarray

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
reverse phase protein lysate microarray; mouse; 1:500; fig 4	Ansari S, Baumer K, BouÃ© S, Dijon S, Dulize R, Ekroos K, et al. Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice. Sci Data. 2016;3:150077 pubmed publisher
	C xf3 rdoba David G, Garc xed a Gim xe9 nez J, Cardoso Castelo Branco R, Carrasco S, Cannata P, Ortiz A, et al. Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury. Front Pharmacol. 2022;13:987979 pubmed publisher
	Bernal S, Lopez Sanz L, Jimenez Castilla L, Prieto I, Melgar A, La Manna S, et al. Protective effect of suppressor of cytokine signalling 1-based therapy in experimental abdominal aortic aneurysm. Br J Pharmacol. 2021;178:564-581 pubmed publisher
	Fu B, Yin S, Lin X, Shi L, Wang Y, Zhang S, et al. PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure. Cell Death Dis. 2020;11:803 pubmed publisher
	Fu B, Xue W, Zhang H, Zhang R, Feldman K, Zhao Q, et al. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. MBio. 2020;11: pubmed publisher
	Botbol Y, Patel B, Macian F. Common Î³-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation. Autophagy. 2015;11:1864-77 pubmed publisher
	Cabanski M, Fields B, Boue S, Boukharov N, Deleon H, Dror N, et al. Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains. Inflamm Res. 2015;64:471-86 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-STAT1 (Tyr701) Polyclonal Antibody

Catalog # :

44-376G

Quantity :

100 µL

Price :

US 566

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: 10 µL, Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of mouse STAT1 that contains tyrosine 701.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 10 µL, Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000

Aliases :

2010005J02Rik; AA408197; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT1; STAT-1; stat1 alpha; STAT91; transcription factor ISGF-3; transcription factor ISGF-3 components p91/p84

more info or order :

Invitrogen product webpage