Phospho-LAT (Tyr132) Polyclonal Antibody | Invitrogen 44-224 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-LAT (Tyr132) Polyclonal Antibody

catalog :

44-224

quantity :

100 uL

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot

citations: 7

Reference
Lo W, Kuhlmann M, Rizzuto G, Ekiz H, Kolawole E, Revelo M, et al. A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat Immunol. 2023;24:676-689 pubmed publisher
Zhang H, Jadhav R, Cao W, Goronzy I, Zhao T, Jin J, et al. Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses. Nat Immunol. 2023;24:96-109 pubmed publisher
Voisinne G, Locard Paulet M, Froment C, Maturin E, Menoita M, Girard L, et al. Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination. Nat Immunol. 2022;23:1355-1364 pubmed publisher
Zeng L, Palaia I, Sarić A, Su X. PLCγ1 promotes phase separation of T cell signaling components. J Cell Biol. 2021;220: pubmed publisher
Guittard G, Dios Esponera A, Palmer D, Akpan I, Barr V, Manna A, et al. The Cish SH2 domain is essential for PLC-Î³1 regulation in TCR stimulated CD8+ T cells. Sci Rep. 2018;8:5336 pubmed publisher
Raab M, Lu Y, Köhler K, Smith X, Strebhardt K, Rudd C. LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation. Nat Commun. 2017;8:16001 pubmed publisher
Manz B, Tan Y, Courtney A, Rutaganira F, Palmer E, Shokat K, et al. Small molecule inhibition of Csk alters affinity recognition by T cells. elife. 2015;4: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-LAT (Tyr132) Polyclonal Antibody

Catalog # :

44-224

Quantity :

100 uL

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 1:1,000

Species :

Human

Isotype :

IgG

Storage :

-20 C

Description :

LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human LAT that contains tyrosine 132.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; Lat; LAT1; linker for activation of T cells; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells; linker for activation of T-cells family member 1; linker protein; p36-38; pp36