Phospho-VE-cadherin (Tyr731) Polyclonal Antibody | Invitrogen 44-1145G product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-VE-cadherin (Tyr731) Polyclonal Antibody

catalog :

44-1145G

quantity :

100 µL

price :

US 500.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 2d	Soni D, Regmi S, Wang D, Debroy A, Zhao Y, Vogel S, et al. Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions. Am J Physiol Lung Cell Mol Physiol. 2017;312:L1003-L1017 pubmed publisher
	Guo J, Terhorst I, Stammer P, Ibrahim A, Oberhuber A, Eierhoff T. The short-chain fatty acid butyrate exerts a specific effect on VE-cadherin phosphorylation and alters the integrity of aortic endothelial cells. Front Cell Dev Biol. 2023;11:1076250 pubmed publisher
	Zeng F, Li Y, Deng Z, He J, Li W, Wang L, et al. SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes. EMBO Mol Med. 2022;14:e14844 pubmed publisher
	Lenin R, Nagy P, Jha K, GANGARAJU R. GRP78 translocation to the cell surface and O-GlcNAcylation of VE-Cadherin contribute to ER stress-mediated endothelial permeability. Sci Rep. 2019;9:10783 pubmed publisher
	Klomp J, Shaaya M, Matsche J, Rebiai R, Aaron J, Collins K, et al. Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response. Cell Chem Biol. 2019;: pubmed publisher
	Soni D, Wang D, Regmi S, Mittal M, Vogel S, Schluter D, et al. Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury. Cell Death Discov. 2018;4:60 pubmed publisher
	Lakshmikanthan S, Sobczak M, Li Calzi S, Shaw L, Grant M, Chrzanowska Wodnicka M. Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier. J Cell Sci. 2018;131: pubmed publisher
	Luo M, Flood E, Almeida D, Yan L, Berlin D, Heerdt P, et al. Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases. J Exp Med. 2017;214:2535-2545 pubmed publisher
	Sivaraj K, Li R, Albarrán Juárez J, Wang S, Tischner D, Grimm M, et al. Endothelial GÎ±q/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015;108:171-80 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-VE-cadherin (Tyr731) Polyclonal Antibody

Catalog # :

44-1145G

Quantity :

100 µL

Price :

US 500.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Non-human primate

Applications :

Immunocytochemistry: 1:100, Western Blot: 1:1,000

Species :

Human, Non-human primate

Isotype :

IgG

Storage :

-20°C

Description :

VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human VE-cadherin that contains tyrosine 731. This sequence is conserved in chimpanzee.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Western Blot: 1:1,000

Aliases :

7B4; 7B4 antigen; 7B4/cadherin-5; AA408225; cadherin 5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); cadherin-5; cadherin-5; cd144 antigen; VE cadherin; Cd144; cd144 antigen; CDH5; cell-cell adhesion protein; endothelial-specific cadherin; vascular endothelial cadherin; vascular endothelial cadherin precursor; Vec; VEcad; VE-Cad; VE-cadherin; VECD

more info or order :

Invitrogen product webpage