Phospho-VE-cadherin (Tyr658) Polyclonal Antibody | Invitrogen 44-1144G product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-VE-cadherin (Tyr658) Polyclonal Antibody

catalog :

44-1144G

quantity :

100 µL

price :

US 460

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse

application :

western blot

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 4f	Peroutka R, Buzza M, Mukhopadhyay S, Johnson T, Driesbaugh K, Antalis T. Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis. PLoS ONE. 2020;15:e0234407 pubmed publisher
	Guo J, Terhorst I, Stammer P, Ibrahim A, Oberhuber A, Eierhoff T. The short-chain fatty acid butyrate exerts a specific effect on VE-cadherin phosphorylation and alters the integrity of aortic endothelial cells. Front Cell Dev Biol. 2023;11:1076250 pubmed publisher
	M xfc ller M, H xfc bner M, Li L, Tomasi S, Lie xdf ke V, Effinger D, et al. Cell-Crossing Functional Network Driven by microRNA-125a Regulates Endothelial Permeability and Monocyte Trafficking in Acute Inflammation. Front Immunol. 2022;13:826047 pubmed publisher
	Tarafdar A, Wolska N, Krisp C, Schluter H, Pula G. The amyloid peptide β disrupts intercellular junctions and increases endothelial permeability in a NADPH oxidase 1-dependent manner. Redox Biol. 2022;52:102287 pubmed publisher
	Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. elife. 2020;9: pubmed publisher
	Schimmel L, Fukuhara D, Richards M, Jin Y, Essebier P, Frampton E, et al. c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly. Development. 2020;147: pubmed publisher
	Chen S, Huang S, Wu C, Hsu C. P-Cresylsulfate, the Protein-Bound Uremic Toxin, Increased Endothelial Permeability Partly Mediated by Src-Induced Phosphorylation of VE-Cadherin. Toxins (Basel). 2020;12: pubmed publisher
	Klomp J, Shaaya M, Matsche J, Rebiai R, Aaron J, Collins K, et al. Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response. Cell Chem Biol. 2019;: pubmed publisher
	Juettner V, Kruse K, Dan A, Vu V, Khan Y, Le J, et al. VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism. J Cell Biol. 2019;218:1725-1742 pubmed publisher
	Lakshmikanthan S, Sobczak M, Li Calzi S, Shaw L, Grant M, Chrzanowska Wodnicka M. Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier. J Cell Sci. 2018;131: pubmed publisher
	Sivaraj K, Li R, Albarrán Juárez J, Wang S, Tischner D, Grimm M, et al. Endothelial GÎ±q/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015;108:171-80 pubmed publisher
	Hahn C, Scott D, Xu X, Roda M, Payne G, Wells J, et al. The matrikine N-Î±-PGP couples extracellular matrix fragmentation to endothelial permeability. Sci Adv. 2015;1: pubmed

product information

Product Type :

Antibody

Product Name :

Phospho-VE-cadherin (Tyr658) Polyclonal Antibody

Catalog # :

44-1144G

Quantity :

100 µL

Price :

US 460

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: 1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20°C

Description :

VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.

Immunogen :

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human VE-cadherin that contains tyrosine 658. This sequence is conserved in chicken, chimpanzee, cow, dog, mouse, pig, and rat.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

7B4; 7B4 antigen; 7B4/cadherin-5; AA408225; cadherin 5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); cadherin-5; cadherin-5; cd144 antigen; VE cadherin; Cd144; cd144 antigen; CDH5; cell-cell adhesion protein; endothelial-specific cadherin; vascular endothelial cadherin; vascular endothelial cadherin precursor; Vec; VEcad; VE-Cad; VE-cadherin; VECD

more info or order :

Invitrogen product webpage