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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MMP2 Monoclonal Antibody (101)
catalog :
436000
quantity :
100 µg
price :
US 450.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
101
reactivity :
human, mouse, rat, Xenopus laevis, domestic rabbit, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; Xenopus laevis; fig 1
Wiechmann A, Ceresa B, Howard E. Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation. PLoS ONE. 2014;9:e113810 pubmed publisher
  • western blot; mouse; fig 1
Morani A, Barros R, Imamov O, Hultenby K, Arner A, Warner M, et al. Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice. Proc Natl Acad Sci U S A. 2006;103:7165-9 pubmed
Kucherenko M, Sang P, Yao J, Gransar T, Dhital S, Grune J, et al. Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease. Nat Commun. 2023;14:4416 pubmed publisher
Yang M, Luo J, Zhang S, Huang Q, Cao Q. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway. Open Med (Wars). 2023;18:20230687 pubmed publisher
Zha Y, Yang Y, Zhou Y, Ye B, Li H, Liang J. Dietary Evodiamine Inhibits Atherosclerosis-Associated Changes in Vascular Smooth Muscle Cells. Int J Mol Sci. 2023;24: pubmed publisher
Shiraishi M, Suzuki K, Yamaguchi A. Effect of mechanical tension on fibroblast transcriptome profile and regulatory mechanisms of myocardial collagen turnover. FASEB J. 2023;37:e22841 pubmed publisher
Tossetta G, Fantone S, Gesuita R, Goteri G, Senzacqua M, Marcheggiani F, et al. Ciliary Neurotrophic Factor Modulates Multiple Downstream Signaling Pathways in Prostate Cancer Inhibiting Cell Invasiveness. Cancers (Basel). 2022;14: pubmed publisher
Shen X, Li L, He Y, Lv X, Ma J. EIF5A2 Is Involved in the Biological Process of Cervical Cancer Cells through AGR2. Pharmacology. 2022;107:376-385 pubmed publisher
Olivera Bravo S, Bolatto C, Otero Damianovich G, Stancov M, Cerri S, Rodr xed guez P, et al. Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis. Sci Rep. 2022;12:4439 pubmed publisher
Nigro E, Mallardo M, Polito R, Scial xf2 F, Bianco A, Daniele A. Adiponectin and Leptin Exert Antagonizing Effects on HUVEC Tube Formation and Migration Modulating the Expression of CXCL1, VEGF, MMP-2 and MMP-9. Int J Mol Sci. 2021;22: pubmed publisher
Morales Vasquez F, Castillo Sanchez R, Gómora M, Almaraz M, Pedernera E, Perez Montiel D, et al. Expression of metalloproteinases MMP-2 and MMP-9 is associated to the presence of androgen receptor in epithelial ovarian tumors. J Ovarian Res. 2020;13:86 pubmed publisher
Bhurke A, Kannan A, Neff A, Ma Q, Laws M, Taylor R, et al. A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules. Proc Natl Acad Sci U S A. 2020;117:14532-14542 pubmed publisher
Łanocha Arendarczyk N, Baranowska Bosiacka I, Gutowska I, Kolasa Wołosiuk A, Kot K, Łanocha A, et al. The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis. Int J Mol Sci. 2018;19: pubmed publisher
Fouad H, Salem H, Ellakwa D, Abdel Hamid M. MMP-2 and MMP-9 as prognostic markers for the early detection of urinary bladder cancer. J Biochem Mol Toxicol. 2019;33:e22275 pubmed publisher
Platen C, Dreschers S, Reiss L, Wappler J, Orlikowsky T. Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and Matrix Metalloproteinases. Mediators Inflamm. 2018;2018:4310419 pubmed publisher
Qian Y, Song J, Sun P, Yi R, Liu H, Feng X, et al. Lactobacillus casei Strain Shirota Enhances the In Vitro Antiproliferative Effect of Geniposide in Human Oral Squamous Carcinoma HSC-3 Cells. Molecules. 2018;23: pubmed publisher
Zandvakili I, Lin Y, Morris J, Zheng Y. Rho GTPases: Anti- or pro-neoplastic targets?. Oncogene. 2017;36:3213-3222 pubmed publisher
Ghorai A, Sarma A, Chowdhury P, Ghosh U. PARP-1 depletion in combination with carbon ion exposure significantly reduces MMPs activity and overall increases TIMPs expression in cultured HeLa cells. Radiat Oncol. 2016;11:126 pubmed
product information
Product Type :
Antibody
Product Name :
MMP2 Monoclonal Antibody (101)
Catalog # :
436000
Quantity :
100 µg
Price :
US 450.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse, Non-human primate, Rabbit, Rat, Rhesus Monkey
Applications :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: Assay-dependent, Western Blot: 2 µg/mL
Species :
Human, Mouse, Non-human primate, Rabbit, Rat, Rhesus Monkey
Clone :
101
Isotype :
IgG1
Storage :
-20°C
Description :
MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
Immunogen :
Recombinant protein derived from the N-terminus of human MMP-2 protein (accession # P08253, NP_004521 ), which is identical to Rhesus monkey and chimpanzee and 98% similar to rat and rabbit and 97% to mouse.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: Assay-dependent, Western Blot: 2 µg/mL
Aliases :
72 kDa gelatinase; 72 kDa type IV collagenase; 72 kDa type IV collagenase isoform a preproprotein; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; CLG 4A; CLG4; CLG4A; Collagenase; collagenase type IV-A; endopeptidase; GelA; gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metallopeptidase 2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloprotease 2; matrix metalloproteinase; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; MMP; MMP2; MMP-2; MMP-2 protein; MMP-II; MMPs; MONA; neutrophil gelatinase; PEX; prepro-72kDa matrix metalloproteinase; Progelatinase A; TBE1; TBE-1; wu:fa99h12; wu:fk89d01
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA