NR5A1 Monoclonal Antibody (N1665) | Invitrogen 434200 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NR5A1 Monoclonal Antibody (N1665)

catalog :

434200

quantity :

100 uL

price :

US 592.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N1665

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 1a	Russell J, Lim X, Santambrogio A, Yianni V, Kemkem Y, Wang B, et al. Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells. elife. 2021;10: pubmed publisher
immunohistochemistry; mouse; 1:200; loading ...; fig 5b	Haston S, Pozzi S, Carreno G, Manshaei S, Panousopoulos L, González Meljem J, et al. MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma. Development. 2017;144:2141-2152 pubmed publisher
immunohistochemistry; human; 1:200; fig 2a	Buonocore F, KÃ¼hnen P, Suntharalingham J, Del Valle I, Digweed M, Stachelscheid H, et al. Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans. J Clin Invest. 2017;127:1700-1713 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; loading ...	Manojlović Gacić E, Skender Gazibara M, Popovic V, Soldatovic I, Boricic N, Raičević S, et al. Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study. Endocr Pathol. 2016;27:1-11 pubmed publisher
immunohistochemistry - paraffin section; human; fig 6	Lewis S, Hedman C, Ziegler T, Ricke W, Jorgensen J. Steroidogenic factor 1 promotes aggressive growth of castration-resistant prostate cancer cells by stimulating steroid synthesis and cell proliferation. Endocrinology. 2014;155:358-69 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100	Kuhn E, Ayhan A, Shih I, Seidman J, Kurman R. Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. Eur J Cancer. 2013;49:3839-49 pubmed publisher
immunohistochemistry - paraffin section; human; fig 6	Straume A, Løvås K, Miletic H, Gravdal K, Lønning P, Knappskog S. Elevated levels of the steroidogenic factor 1 are associated with over-expression of CYP19 in an oestrogen-producing testicular Leydig cell tumour. Eur J Endocrinol. 2012;166:941-9 pubmed publisher
immunohistochemistry - frozen section; human; 1:200; fig 5	Ferraz de Souza B, Lin L, Shah S, Jina N, Hubank M, Dattani M, et al. ChIP-on-chip analysis reveals angiopoietin 2 (Ang2, ANGPT2) as a novel target of steroidogenic factor-1 (SF-1, NR5A1) in the human adrenal gland. FASEB J. 2011;25:1166-75 pubmed publisher
	Malolina E, Galiakberova A, Dashinimaev E, Kulibin A. Establishment of a pure culture of immature Sertoli cells by PDGFRA staining and cell sorting. Mol Reprod Dev. 2022;89:243-255 pubmed publisher
	Tjörnstrand A, Casar Borota O, Heurling K, Scholl M, Gjertsson P, Ragnarsson O, et al. Pre- and postoperative 68 Ga-DOTATOC positron emission tomography for hormone-secreting pituitary neuroendocrine tumours. Clin Endocrinol (Oxf). 2021;: pubmed publisher
	Hickman R, Bruce J, Otten M, Khandji A, Flowers X, Siegelin M, et al. Gonadotroph tumours with a low SF-1 labelling index are more likely to recur and are associated with enrichment of the PI3K-AKT pathway. Neuropathol Appl Neurobiol. 2021;47:415-427 pubmed publisher
	Fagan M, Ameroso D, Meng A, Rock A, Maguire J, Rios M. Essential and sex-specific effects of mGluR5 in ventromedial hypothalamus regulating estrogen signaling and glucose balance. Proc Natl Acad Sci U S A. 2020;117:19566-19577 pubmed publisher
	Tamanini J, Dal Fabbro M, de Freitas L, Vassallo J, de Souza Queiroz L, Rogerio F. Digital analysis of hormonal immunostaining in pituitary adenomas classified according to WHO 2017 criteria and correlation with preoperative laboratory findings. Neurosurg Focus. 2020;48:E12 pubmed publisher
	Janjic M, Prévide R, Fletcher P, Sherman A, Smiljanic K, Abebe D, et al. Divergent expression patterns of pituitary gonadotropin subunit and GnRH receptor genes to continuous GnRH in vitro and in vivo. Sci Rep. 2019;9:20098 pubmed publisher
	Osakabe M, Sato C, Suzuki M, Sugimoto R, Fujita Y, Uesugi N, et al. Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report. Diagn Pathol. 2019;14:27 pubmed publisher
	Portnoi M, Dumargne M, Rojo S, Witchel S, Duncan A, Eozenou C, et al. Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies. Hum Mol Genet. 2018;27:1228-1240 pubmed publisher
	Del Valle I, Buonocore F, Duncan A, Lin L, Barenco M, Parnaik R, et al. A genomic atlas of human adrenal and gonad development. Wellcome Open Res. 2017;2:25 pubmed publisher
	Blanco L, Kuhn E, Morrison J, Bahadirli Talbott A, Smith Sehdev A, Kurman R. Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis. Mod Pathol. 2017;30:563-576 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NR5A1 Monoclonal Antibody (N1665)

Catalog # :

434200

Quantity :

100 uL

Price :

US 592.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: 0.1 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 3 ug/mL

Species :

Human, Mouse, Rat

Clone :

N1665

Isotype :

IgG1

Storage :

Maintain refrigerated at 2-8 C for up to 1 month. For long term storage store at -20 C

Description :

Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. SF-1 has been shown to be essential for fetal development of the hypothalamus, pituitary gland, gonads, and the adrenal gland. SF-1 has been shown to promote transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family. SF-1 contains two activation function domains, designated AF1 and AF2, common to many nuclear steroid receptors which have been shown to be necessary for interaction with other nuclear receptors as well as coactivators and corepressors including steroid receptor coactivator-1 (SRC-1), glucocorticoid receptor interacting protein 1 (GRIP1), cAMP response element binding protein (CREB) binding protein (CBP) and silencing mediator of retinoid acid and thyroid hormone receptor (SMRT).

Immunogen :

BALB/c mouse immunized with E.coli-expressed recombinant human SF-1 (218-461aa).

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.1 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 3 ug/mL

Aliases :

Ad4BP; Ad4BP/SF-1; adrenal 4 binding protein; Adrenal 4 binding protein (AD4BP); adrenal 4-binding protein; ELP; ELP-3; Embryonal long terminal repeat-binding protein; embryonal LTR-binding protein; FTZ1; FTZF1; Ftz-F1; fushi tarazu 1 factor homolog; fushi tarazu factor homolog 1; Fushi tarazu factor homolog 1 (FTZ1); hSF-1; Nr5a1; nuclear receptor AdBP4; nuclear receptor subfamily 5 group A member 1; Nuclear receptor subfamily 5 group A member 1 (NR5A1); nuclear receptor subfamily 5, group A, member 1; POF7; SF1; SF-1; SPGF8; SRXY3; Steroid hormone receptor Ad4BP; steroid hydroxylase positive regulator; Steroidogenic factor 1; Steroidogenic factor 1 (SF1); steroidogenic factor 1 nuclear receptor; steroidogenic factor-1; STF1; STF-1

more info or order :

Invitrogen product webpage