Pannexin 3 Polyclonal Antibody | Invitrogen 433270 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Pannexin 3 Polyclonal Antibody

catalog :

433270

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 3

Reference
Leroy K, Vilas Boas V, Gijbels E, Vanderborght B, Devisscher L, Cogliati B, et al. Expression of connexins and pannexins in diseased human liver. EXCLI J. 2022;21:1111-1129 pubmed publisher
Hainz N, Beckmann A, Schubert M, Haase A, Martin U, Tschernig T, et al. Human stem cells express pannexins. BMC Res Notes. 2018;11:54 pubmed publisher
Guerrero J, Oliveira H, Aid R, Bareille R, Siadous R, Letourneur D, et al. Influence of the three-dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3. J Tissue Eng Regen Med. 2017;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Pannexin 3 Polyclonal Antibody

Catalog # :

433270

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 1 month. For long term storage store at -20 C

Description :

Pannexins constitute a new family of gap junction type proteins. They are highly conserved in worms, mollusks, insects and mammals and are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop and intracellular N- and C-termini. Besides the connexin proteins, Pannexin 1 and 2 seem to be molecular components of neuronal gap junctions ('electrical synapses') that are thought to form connections between principal cells in the hippocampus. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions. In addition to forming gap junction channels in paired oocytes, Pannexin 1 can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Pannexin 1 and 3 are both glycoproteins with a cell surface distribution profile and life cycle dynamics distinct from connexin 43. Pannexin 3 expression was prevalent in skin and cartilage. In transiently expressing cells both pannexin 1 and 3 were incapable of forming intercellular channels but assembled into functional cell surface channels. Suggested roles in the ischemic death of neurons, schizophrenia, inflammation and tumor suppression have drawn attention for properties and cellular functions of pannexins.

Immunogen :

Synthetic peptide derived from the C-terminal region of the mouse and rat Pannexin 3 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Western Blot: Assay-dependent

Aliases :

3230401P04; 4833413G11Rik; gap junction protein pannexin 3; pannexin 3; pannexin-3; Panx3; Px3; si:dkey-263o8.2