Caspase 3 Monoclonal Antibody (74T2) | Invitrogen 43-7800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Caspase 3 Monoclonal Antibody (74T2)

catalog :

43-7800

quantity :

100 µg

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

74T2

reactivity :

human, mouse, rat, domestic horse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; 1:100; loading ...; fig 3	Grzesiak J, Smieszek A, Marycz K. Ultrastructural changes during osteogenic differentiation in mesenchymal stromal cells cultured in alginate hydrogel. Cell Biosci. 2017;7:2 pubmed publisher
	Tregub P, Malinovskaya N, Hilazheva E, Morgun A, Kulikov V. Permissive hypercapnia and hypercapnic hypoxia inhibit signaling pathways of neuronal apoptosis in ischemic/hypoxic rats. Mol Biol Rep. 2023;50:2317-2333 pubmed publisher
	Bagge J, Padma A, Casselbrant A, Hellstr xf6 m M, Oltean M. Mucosal Recovery after Intestinal Transplantation in the Rat: A Sequential Histological and Molecular Assessment. Eur Surg Res. 2023;64:201-210 pubmed publisher
	Elhady S, Abdelhameed R, Mehanna E, Wahba A, Elfaky M, Koshak A, et al. Metabolic Profiling, Chemical Composition, Antioxidant Capacity, and In Vivo Hepato- and Nephroprotective Effects of Sonchus cornutus in Mice Exposed to Cisplatin. Antioxidants (Basel). 2022;11: pubmed publisher
	Zhang S, Yu H, Li J, Fan J, Chen J. 2-Methoxyestradiol combined with ascorbic acid facilitates the apoptosis of chronic myeloid leukemia cells via the microRNA-223/Fms-like tyrosine kinase 3/phosphatidylinositol-3 kinase/protein kinase B axis. Bioengineered. 2022;13:3470-3485 pubmed publisher
	Li Y, Li A, Wang C, Jin X, Zhang Y, Lu L, et al. The Ganglioside Monosialotetrahexosylganglioside Protects Auditory Hair Cells Against Neomycin-Induced Cytotoxicity Through Mitochondrial Antioxidation: An in vitro Study. Front Cell Neurosci. 2021;15:751867 pubmed publisher
	Wan H, Yang Y, Li Z, Cheng L, Ding Z, Wan H, et al. Compatibility of ingredients of Danshen (Radix Salviae Miltiorrhizae) and Honghua (Flos Carthami) and their protective effects on cerebral ischemia-reperfusion injury in rats. Exp Ther Med. 2021;22:849 pubmed publisher
	Abedin M, Powers K, Aiardo R, Barua D, Barua S. Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells. Sci Rep. 2021;11:7347 pubmed publisher
	Marycz K, Sobierajska P, Wiglusz R, Idczak R, Nedelec J, Fal A, et al. Fe3O4 Magnetic Nanoparticles Under Static Magnetic Field Improve Osteogenesis via RUNX-2 and Inhibit Osteoclastogenesis by the Induction of Apoptosis. Int J Nanomedicine. 2020;15:10127-10148 pubmed publisher
	Marycz K, Sobierajska P, Roecken M, Kornicka Garbowska K, Kepska M, Idczak R, et al. Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action. J Nanobiotechnology. 2020;18:33 pubmed publisher
	Kornicka K, Szłapka Kosarzewska J, Smieszek A, Marycz K. 5-Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy. J Cell Mol Med. 2019;23:237-259 pubmed publisher
	Lei X, Lei L, Zhang Z, Cheng Y. Diazoxide inhibits of ER stress‑mediated apoptosis during oxygen‑glucose deprivation in vitro and cerebral ischemia‑reperfusion in vivo. Mol Med Rep. 2018;17:8039-8046 pubmed publisher
	Marycz K, Kornicka K, Szlapka Kosarzewska J, Weiss C. Excessive Endoplasmic Reticulum Stress Correlates with Impaired Mitochondrial Dynamics, Mitophagy and Apoptosis, in Liver and Adipose Tissue, but Not in Muscles in EMS Horses. Int J Mol Sci. 2018;19: pubmed publisher
	Ady J, Thayanithy V, Mojica K, Wong P, Carson J, Rao P, et al. Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection. Mol Ther Oncolytics. 2016;3:16029 pubmed

product information

Product Type :

Antibody

Product Name :

Caspase 3 Monoclonal Antibody (74T2)

Catalog # :

43-7800

Quantity :

100 µg

Price :

US 450.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Equine, Human, Mouse, Non-human primate, Rat

Applications :

Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 2 µg/mL

Species :

Equine, Human, Mouse, Non-human primate, Rat

Clone :

74T2

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Immunogen :

Recombinant protein derived from the N-terminus of human Caspase 3 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 2 µg/mL

Aliases :

A830040C14Rik; AC-3; Apopain; Apopain precursor; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase3; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; Caspase-3-like protein; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; cysteine protease; CPP32; apopain; ICE3; IRP; LICE; mldy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein

more info or order :

Invitrogen product webpage