CYLD Monoclonal Antibody (733) | Invitrogen 43-7700 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CYLD Monoclonal Antibody (733)

catalog :

43-7700

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

733

The same clone is also sold as:

Abcam: ab200476

reactivity :

human, mouse, rat, bovine, domestic horse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
Hotta T, McAlear T, Yue Y, Higaki T, Haynes S, Nesvizhskii A, et al. EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules. Curr Biol. 2022;32:3898-3910.e14 pubmed publisher
Wang X, Li Y, Liu S, Yu X, Li L, Shi C, et al. Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Proc Natl Acad Sci U S A. 2014;111:15438-43 pubmed publisher
Liu S, Wang X, Li Y, Xu L, Yu X, Ge L, et al. Necroptosis mediates TNF-induced toxicity of hippocampal neurons. Biomed Res Int. 2014;2014:290182 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CYLD Monoclonal Antibody (733)

Catalog # :

43-7700

Quantity :

100 ug

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Equine, Human, Mouse, Non-human primate, Rat

Applications :

Immunocytochemistry: 1 ug/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1,000

Species :

Bovine, Equine, Human, Mouse, Non-human primate, Rat

Clone :

733

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

Immunogen :

Recombinant protein derived from the N-terminus of human CYLD protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1 ug/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1,000

Aliases :

2010013M14Rik; 2900009M21Rik; BRSS; C130039D01Rik; CDMT; Cyld; CYLD lysine 63 deubiquitinase; CYLD1; CYLDI; cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; EAC; FLJ20180; FLJ31664; FLJ78684; HSPC057; KIAA0849; LRRGT00003; MFT; MFT1; mKIAA0849; probable ubiquitin carboxyl-terminal hydrolase CYLD; retinitis pigmentosa 1 homolog; Rp1; Rp1h; SBS; TEM; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD; Unknown (protein for MGC:137952); USPL2