PCNA Monoclonal Antibody (PC10 (3F81)), eFluor 615, eBioscience | Invitrogen 42-9910-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PCNA Monoclonal Antibody (PC10 (3F81)), eFluor 615, eBioscience

catalog :

42-9910-82

quantity :

100 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

eFluor 615

clone name :

PC10 (3F81)

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry

citations: 4

Reference
Woods A, Hall P, Shepherd N, Hanby A, Waseem N, Lane D, et al. The assessment of proliferating cell nuclear antigen (PCNA)immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis. Histopathology. 2002;41:165-71 pubmed
Hall P, Levison D, Woods A, Yu C, Kellock D, Watkins J, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol. 1990;162:285-94 pubmed
Waseem N, Lane D. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. J Cell Sci. 1990;96 ( Pt 1):121-9 pubmed
Landberg G, Roos G. Antibodies to proliferating cell nuclear antigen as S-phase probes in flow cytometric cell cycle analysis. Cancer Res. 1991;51:4570-4 pubmed

product information

Product Type :

Antibody

Product Name :

PCNA Monoclonal Antibody (PC10 (3F81)), eFluor 615, eBioscience

Catalog # :

42-9910-82

Quantity :

100 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 0.5 ug/mL, Immunohistochemistry: Assay-Dependent

Species :

Human, Mouse, Rat

Clone :

PC10 (3F81)

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 0.5 ug/mL, Immunohistochemistry: Assay-Dependent

Aliases :

ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; hypothetical protein LOC515499; MGC8367; Pcna; pcna protein; Pcna/cyclin; PCNAR; POL30; Proliferating cell nuclear antigen; wu:fa28e03; wu:fb36g03; YBR0811; YBR088C