TBX3 Polyclonal Antibody | Invitrogen 42-4800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TBX3 Polyclonal Antibody

catalog :

42-4800

quantity :

100 µg

price :

US 430.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:25; fig 3 western blot; mouse; 1:25; fig 3	Willmer T, Cooper A, Sims D, Govender D, Prince S. The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes. Oncogenesis. 2016;5:e199 pubmed publisher
	Lu A, Gu R, Chu C, Xia Y, Wang J, Davis D, et al. Inhibition of Wnt/β-catenin signaling upregulates Nav 1.5 channels in Brugada syndrome iPSC-derived cardiomyocytes. Physiol Rep. 2023;11:e15696 pubmed publisher
	Hwang J, Arafeh R, Seo J, Baca S, Ludwig M, Arnoff T, et al. CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies. elife. 2022;11: pubmed publisher
	Zhang P, Guan H, Yuan S, Cheng H, Zheng J, Zhang Z, et al. Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors. Nat Commun. 2022;13:1588 pubmed publisher
	Goodwin K, Jaslove J, Tao H, Zhu M, Hopyan S, Nelson C. Patterning the embryonic pulmonary mesenchyme. iScience. 2022;25:103838 pubmed publisher
	Willmer T, Damerell V, Smyly S, Sims D, Du Toit M, Ncube S, et al. Targeting the oncogenic TBX3:nucleolin complex to treat multiple sarcoma subtypes. Am J Cancer Res. 2021;11:5680-5700 pubmed
	Washausen S, Knabe W. Lateral line placodes of aquatic vertebrates are evolutionarily conserved in mammals. Biol Open. 2018;7: pubmed publisher
	Shimbo T, Dunnick J, Brix A, Mav D, Shah R, Roberts J, et al. DNA Methylation Changes in Tbx3 in a Mouse Model Exposed to Polybrominated Diphenyl Ethers. Int J Toxicol. 2017;36:229-238 pubmed publisher
	Willmer T, Hare S, Peres J, Prince S. The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor. Cell Div. 2016;11:6 pubmed publisher
	Willmer T, Peres J, Mowla S, Abrahams A, Prince S. The T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin A-CDK2. Cell Cycle. 2015;14:3173-83 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TBX3 Polyclonal Antibody

Catalog # :

42-4800

Quantity :

100 µg

Price :

US 430.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: 1:1,000, Immunohistochemistry (Paraffin): 1:1,000, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 µg/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.

Immunogen :

Synthetic peptide derived from an internal region of human T-box 3, which differs from mouse and rat by one conservative and one non-conservative amino acid

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:1,000, Immunohistochemistry (Paraffin): 1:1,000, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 µg/mL

Aliases :

bladder cancer related protein XHL; D5Ertd189e; T-box 3; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3; TBX3; TBX3-ISO; UMS; XHL

more info or order :

Invitrogen product webpage