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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Sigma-1 Receptor Polyclonal Antibody
catalog :
42-3300
quantity :
100 µg
price :
US 450.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
mouse, rat
application :
western blot, immunohistochemistry knockout validation
more info or order :
Invitrogen product webpage
citations: 17
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; fig 2
Mavlyutov T, Duellman T, Kim H, Epstein M, Leese C, Davletov B, et al. Sigma-1 receptor expression in the dorsal root ganglion: Reexamination using a highly specific antibody. Neuroscience. 2016;331:148-57 pubmed publisher
Garz xf3 n Ni xf1 o J, Cort xe9 s Montero E, Rodr xed guez Mu xf1 oz M, S xe1 nchez Bl xe1 zquez P. αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers. Int J Mol Sci. 2022;24: pubmed publisher
Song L, Bekdash R, Morikawa K, Quejada J, Klein A, Aina Badejo D, et al. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat Cardiovasc Res. 2022;1:142-156 pubmed publisher
Rodr xed guez Mu xf1 oz M, Cort xe9 s Montero E, Onetti Y, S xe1 nchez Bl xe1 zquez P, Garz xf3 n Ni xf1 o J. The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain. Biomolecules. 2021;11: pubmed publisher
Hoffman A, Watson S, Fanselow M, Hovda D, GIZA C. Region-Dependent Modulation of Neural Plasticity in Limbic Structures Early after Traumatic Brain Injury. Neurotrauma Rep. 2021;2:200-213 pubmed publisher
Cortés Montero E, Rodríguez Muñoz M, Ruiz Cantero M, Cobos E, Sánchez Blázquez P, Garzón Niño J. Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue. Int J Mol Sci. 2020;22: pubmed publisher
Rodríguez Muñoz M, Cortés Montero E, Garzón Niño J, Sánchez Blázquez P. The ALS-related σ1R E102Q Mutant Eludes Ligand Control and Exhibits Anomalous Response to Calcium. Int J Mol Sci. 2020;21: pubmed publisher
Cortés Montero E, Sánchez Blázquez P, Onetti Y, Merlos M, Garzón J. Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels. Front Pharmacol. 2019;10:634 pubmed publisher
Cortés Montero E, Rodríguez Muñoz M, Sánchez Blázquez P, Garzón J. The axonal motor neuropathy-related HINT1 protein is a zinc- and calmodulin-regulated cysteine SUMO protease. Antioxid Redox Signal. 2019;: pubmed publisher
Wu S, Lu Q, Ding Y, Wu Y, Qiu Y, Wang P, et al. Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo. Circulation. 2019;139:1913-1936 pubmed publisher
Rodríguez Muñoz M, Onetti Y, Cortés Montero E, Garzón J, Sánchez Blázquez P. Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 2018;11:51 pubmed publisher
Sambo D, Lin M, Owens A, Lebowitz J, Richardson B, Jagnarine D, et al. The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission. Nat Commun. 2017;8:2228 pubmed publisher
Shen B, Behera D, James M, Reyes S, Andrews L, Cipriano P, et al. Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI. Theranostics. 2017;7:2794-2805 pubmed publisher
Trujillo A, Katnik C, Cuevas J, Cha B, Taylor Clark T, Breslin J. Modulation of mesenteric collecting lymphatic contractions by ?1-receptor activation and nitric oxide production. Am J Physiol Heart Circ Physiol. 2017;313:H839-H853 pubmed publisher
Hosszú A, Antal Z, Lenart L, Hodrea J, Koszegi S, Balogh D, et al. ?1-Receptor Agonism Protects against Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2017;28:152-165 pubmed publisher
Rodríguez Muñoz M, Cortés Montero E, Pozo Rodrigálvarez A, Sánchez Blázquez P, Garzón Niño J. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Oncotarget. 2015;6:35458-77 pubmed publisher
Rodríguez Muñoz M, Sánchez Blázquez P, Herrero Labrador R, Martínez Murillo R, Merlos M, Vela J, et al. The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control. Antioxid Redox Signal. 2015;22:799-818 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Sigma-1 Receptor Polyclonal Antibody
Catalog # :
42-3300
Quantity :
100 µg
Price :
US 450.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Mouse, Rat
Applications :
Western Blot: 2 µg/mL
Species :
Mouse, Rat
Isotype :
IgG
Storage :
-20°C
Description :
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
Immunogen :
Synthetic peptide derived from the C-terminal region of the rat sigma-1 receptor, which differs from mouse and human by one conservative amino acid change and is predicted to be identical to dog, bovine, and ermine
Format :
Liquid
Applications w/Dilutions :
Western Blot: 2 µg/mL
Aliases :
AAG8; Aging-associated gene 8 protein; AL024364; ALS16; DSMA2; hSigmaR1; mSigmaR1; opioid receptor, sigma 1; Oprs1; RP23 167I12.6; SIG 1R; SIG-1R; sigma 1 receptor variant SR-1D; sigma 1-type opioid receptor; Sigma non-opioid intracellular receptor 1; sigma1 receptor; Sigma-1 Receptor; sigma1R; sigma1-receptor; Sigmar1; SR BP; SR31747 binding protein 1; SR31747-binding protein; SRBP; SR-BP; SR-BP1; zgc:56378
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA