Pannexin 2 Polyclonal Antibody | Invitrogen 42-2900 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Pannexin 2 Polyclonal Antibody

catalog :

42-2900

quantity :

100 ug

price :

US 419.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Leroy K, Vilas Boas V, Gijbels E, Vanderborght B, Devisscher L, Cogliati B, et al. Expression of connexins and pannexins in diseased human liver. EXCLI J. 2022;21:1111-1129 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Pannexin 2 Polyclonal Antibody

Catalog # :

42-2900

Quantity :

100 ug

Price :

US 419.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 2-3 ug/mL, Immunohistochemistry (Paraffin): 1:20, Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Gap junctions are channel-forming structures that allow direct metabolic and electrical communication between adjacent cells of almost all types in mammalian tissues. In the human body, they are absent only in adult skeletal muscle cells and some circulating blood cells. A gap junction is formed two hemichannels, one in each of the neighboring cells, composed of six subunits. In mice and humans, at least 20 connexin and 3 pannexin genes encode gap junction proteins. Connexins are only found in chordates, while pannexins are present in both chordate and invertebrate genomes. Pannexins, previously known as innexins, are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini. Both human and mouse genomes contain three pannexin-encoded genes. Pannexin 2 (Px2, PANX2) appears to be a brain specific gene, and is abundantly expressed in the central nervous system, as is pannexin 1. In many neuronal cell populations, including hippocampus, olfactory bulb, cortex, and cerebellum, pannexin 1 and pannexin 2 are co-expressed; in other brain regions such as white matter, only pannexin 1-positive cells are found.

Immunogen :

Synthetic peptide derived from an internal region of human, mouse, and rat pannexin 2, which is identical to predicted bovine and dog sequence

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2-3 ug/mL, Immunohistochemistry (Paraffin): 1:20, Western Blot: Assay-dependent

Aliases :

h PX2; hPANX2; pannexin 2; pannexin-2; PANX2; Px2; si:ch211-192n14.2