MUPP1 Polyclonal Antibody | Invitrogen 42-2700 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MUPP1 Polyclonal Antibody

catalog :

42-2700

quantity :

100 µg

price :

US 430.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; fig ev1d	Feldner A, Adam M, Tetzlaff F, Moll I, Komljenovic D, Sahm F, et al. Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med. 2017;9:890-905 pubmed publisher
	Bharadwaj T, Schrauwen I, Rehman S, Liaqat K, Acharya A, Giese A, et al. ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment. Eur J Hum Genet. 2022;30:22-33 pubmed publisher
	Tetzlaff F, Adam M, Feldner A, Moll I, Menuchin A, Rodriguez Vita J, et al. MPDZ promotes DLL4-induced Notch signaling during angiogenesis. elife. 2018;7: pubmed publisher

product information

Product Type :

Antibody

Product Name :

MUPP1 Polyclonal Antibody

Catalog # :

42-2700

Quantity :

100 µg

Price :

US 430.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Mouse

Applications :

Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Isotype :

IgG

Storage :

-20°C

Description :

MUPP1 (multi PDZ domain protein 1, MPDZ) was discovered as an interacting partner with the 5-HT2C receptor1, and was found to co-localize with 5-HT2A or 5-HT2C receptors in all regions of the mouse brain, including the choroid plexus. MUPP1 contains 13 PDZ domains but no apparent catalytic domain. MUPP1 is concentrated in tight junctions of polarized epithelial cells and binds to claudin-1 and junctional adhesion molecule (JAM). MUPP1 may therefore function as a multivalent scaffold protein that recruits various proteins to tight junctions. MUPP1 also interacts with claudin-8 and may play a role in tight junction barrier function.

Immunogen :

Synthetic peptide derived from the C-terminal region of mouse MUPP1

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Aliases :

AI225843; B930003D11Rik; DKFZp781P216; FLJ25909; FLJ34626; FLJ90240; HYC2; LOW QUALITY PROTEIN: multiple PDZ domain protein; MPDZ; Multi-PDZ domain protein 1; multiple PDZ domain crumbs cell polarity complex component; multiple PDZ domain protein; Mupp1

more info or order :

Invitrogen product webpage