This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (4SM95), eFluor 570, eBioscience
catalog :
41-9766-82
quantity :
100 ug
price :
US 471.00
clonality :
monoclonal
host :
rat
conjugate :
eFluor 570
clone name :
4SM95
reactivity :
mouse
application :
immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 38
Reference
Josi R, Speiser D, de Brot S, Vogt A, Sevick Muraca E, Tolstonog G, et al. A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation. iScience. 2024;27:109439 pubmed publisher
Lee S, Pan J, Xiong D, Palen K, Johnson B, Lubet R, et al. Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention. NPJ Precis Oncol. 2023;7:108 pubmed publisher
Digifico E, Erreni M, Mannarino L, Marchini S, Ummarino A, Anfray C, et al. Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma. Front Immunol. 2023;14:1116430 pubmed publisher
Zhang Y, Rahman M, Clark P, Sriramaneni R, Havighurst T, Kerr C, et al. In Situ Vaccination Following Intratumoral Injection of IL2 and Poly-l-lysine/Iron Oxide/CpG Nanoparticles to a Radiated Tumor Site. ACS Nano. 2023;17:10236-10251 pubmed publisher
Mej xed a Hern xe1 ndez J, Keam S, Saleh R, Muntz F, Fox S, Byrne D, et al. Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss. Cell Death Dis. 2022;13:777 pubmed publisher
Guo L, Li N, Yang Z, Li H, Zheng H, Yang J, et al. Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection. Front Immunol. 2021;12:785457 pubmed publisher
Qadir A, Guegan J, Ginestier C, Chaibi A, Bessede A, Charafe Jauffret E, et al. CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells. iScience. 2021;24:103348 pubmed publisher
Pang L, Ernst M, Huynh J. Development of a Multiplex Immunohistochemistry Workflow to Investigate the Immune Microenvironment in Mouse Models of Inflammatory Bowel Disease and Colon Cancer. Int J Mol Sci. 2021;22: pubmed publisher
Vito A, Salem O, El Sayes N, MacFawn I, Portillo A, Milne K, et al. Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells. Commun Biol. 2021;4:859 pubmed publisher
Li M, McGhee E, Shinno L, Lee K, Lin Y. Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo. Am J Pathol. 2021;191:1822-1836 pubmed publisher
Taranto D, Ramirez C, Vegna S, de Groot M, de Wit N, van Baalen M, et al. Multiparametric Analyses of Hepatocellular Carcinoma Somatic Mouse Models and Their Associated Tumor Microenvironment. Curr Protoc. 2021;1:e147 pubmed publisher
Vito A, Rathmann S, Mercanti N, El Sayes N, Mossman K, Valliant J. Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer. Int J Mol Sci. 2021;22: pubmed publisher
Zhang J, Zheng Y, Lee J, Hua J, Li S, Panchamukhi A, et al. A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing. Nat Commun. 2021;12:1670 pubmed publisher
Pang L, Huynh J, Alorro M, Li X, Ernst M, Chand A. STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis. Biomedicines. 2021;9: pubmed publisher
Wang H, Zhang C, Fang B, Hou J, Li W, Li Z, et al. Dual Role of Hepatic Macrophages in the Establishment of the Echinococcus multilocularis Metacestode in Mice. Front Immunol. 2020;11:600635 pubmed publisher
Bianchi A, Marchetti L, Hall Z, Lemos H, Vacca M, Paish H, et al. Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis. J Immunol. 2021;206:904-916 pubmed publisher
Maller O, Drain A, Barrett A, Borgquist S, Ruffell B, Zakharevich I, et al. Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. Nat Mater. 2021;20:548-559 pubmed publisher
Lundy S, Richardson S, Ramsey A, Ellerson D, Fengxia Y, Onyeabor S, et al. Shift work influences the outcomes of Chlamydia infection and pathogenesis. Sci Rep. 2020;10:15389 pubmed publisher
Richardson L, Nieman L, Stemmer Rachamimov A, Zheng X, Stafford K, Nagashima H, et al. IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice. Oncoimmunology. 2020;9:1806662 pubmed publisher
Hoefflin R, Harlander S, Schäfer S, Metzger P, Kuo F, Schönenberger D, et al. HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. Nat Commun. 2020;11:4111 pubmed publisher
Alvero A, Hanlon D, Pitruzzello M, Filler R, Robinson E, Sobolev O, et al. Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer. Oncoimmunology. 2020;9:1758869 pubmed publisher
Bergamaschi C, Pandit H, Nagy B, Stellas D, Jensen S, Bear J, et al. Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10. J Immunother Cancer. 2020;8: pubmed publisher
Saha D, Rabkin S, Martuza R. Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma. J Immunother Cancer. 2020;8: pubmed publisher
von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
Thomas S, Kuncheria L, Roulstone V, Kyula J, Mansfield D, Bommareddy P, et al. Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1. J Immunother Cancer. 2019;7:214 pubmed publisher
Raninga P, Lee A, Sinha D, Shih Y, Mittal D, Makhale A, et al. Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer. Int J Cancer. 2020;146:123-136 pubmed publisher
Messenger Z, Hall J, Jima D, House J, Tam H, Tokarz D, et al. C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event. Cell Death Dis. 2018;9:1054 pubmed publisher
Xiao R, Bergin S, Huang W, Mansour A, Liu X, Judd R, et al. Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice. Brain Behav Immun. 2019;75:137-148 pubmed publisher
Li H, McSharry M, Walker D, Johnson A, Kwak J, Bullock B, et al. Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II. Oncoimmunology. 2018;7:e1423182 pubmed publisher
Saha D, Wakimoto H, Peters C, Antoszczyk S, Rabkin S, Martuza R. Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models. Clin Cancer Res. 2018;24:3409-3422 pubmed publisher
Yan X, Wang L, Zhang R, Pu X, Wu S, Yu L, et al. Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy. Oncoimmunology. 2017;7:e1376156 pubmed publisher
Jaini R, Loya M, Eng C. Immunotherapeutic target expression on breast tumors can be amplified by hormone receptor antagonism: a novel strategy for enhancing efficacy of targeted immunotherapy. Oncotarget. 2017;8:32536-32549 pubmed publisher
Jin Z, Liang F, Yang J, Mei W. hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer. PLoS Genet. 2017;13:e1006672 pubmed publisher
Hirai Yuki A, Hensley L, McGivern D, Gonzalez Lopez O, Das A, Feng H, et al. MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science. 2016;353:1541-1545 pubmed
Kroon P, Gadiot J, Peeters M, Gasparini A, Deken M, Yagita H, et al. Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma. Cancer Immunol Immunother. 2016;65:753-63 pubmed publisher
Seo J, Bang M, Kim G, Cho S, Park D. Erythronium japonicum attenuates histopathological lung abnormalities in a mouse model of ovalbumin-induced asthma. Int J Mol Med. 2016;37:1221-8 pubmed publisher
Marek I, Lichtneger T, Cordasic N, Hilgers K, Volkert G, Fahlbusch F, et al. Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover. PLoS ONE. 2016;11:e0150471 pubmed publisher
Wang D, Mou H, Li S, Li Y, Hough S, Tran K, et al. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Hum Gene Ther. 2015;26:432-42 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (4SM95), eFluor 570, eBioscience
Catalog # :
41-9766-82
Quantity :
100 ug
Price :
US 471.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Immunocytochemistry: 20 ug/mL, Immunohistochemistry (Paraffin): 20 ug/mL
Species :
Mouse
Clone :
4SM95
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 20 ug/mL, Immunohistochemistry (Paraffin): 20 ug/mL
Aliases :
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA