This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Alpha-Smooth Muscle Actin Monoclonal Antibody (1A4), eFluor 570, eBioscience
catalog :
41-9760-80
quantity :
25 ug
price :
US 171.00
clonality :
monoclonal
host :
mouse
conjugate :
eFluor 570
clone name :
1A4

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 30
Reference
Wu Z, Thierry K, Bachy S, Zhang X, Gamradt P, Hernandez Vargas H, et al. Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer. EMBO Rep. 2023;24:e56524 pubmed publisher
Rodriguez E, Boelaars K, Brown K, Madunić K, van Ee T, Dijk F, et al. Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits. Commun Biol. 2022;5:41 pubmed publisher
Hassel C, Gausser xe8 s B, Guzylack Piriou L, Foucras G. Ductal Macrophages Predominate in the Immune Landscape of the Lactating Mammary Gland. Front Immunol. 2021;12:754661 pubmed publisher
Nagavally R, Sunilkumar S, Akhtar M, Trombetta L, Ford S. Chrysin Ameliorates Cyclosporine-A-Induced Renal Fibrosis by Inhibiting TGF-β1-Induced Epithelial-Mesenchymal Transition. Int J Mol Sci. 2021;22: pubmed publisher
El Sherbiny M, Atef H, Eladl M, Mohamed A, El Shafey M, Ali H, et al. Leflunomide Induces Dose-Dependent Lung Injury in Mice via Stimulating Vimentin and NLRP3 Inflammasome Production. Front Pharmacol. 2021;12:631216 pubmed publisher
Zhang L, He J, Wang J, Liu J, Chen Z, Deng B, et al. Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy. Cell Death Dis. 2021;12:470 pubmed publisher
Gilmore A, Flaherty S, Somasundaram V, Scheiblin D, Lockett S, Wink D, et al. An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients. Commun Biol. 2021;4:477 pubmed publisher
Xu Y, Wang N, Tan H, Li S, Zhang C, Feng Y. Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease. Hepatol Int. 2021;15:350-365 pubmed publisher
Panera N, Meroni M, Longo M, Crudele A, Valenti L, Bellacchio E, et al. The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation. EBioMedicine. 2021;65:103249 pubmed publisher
Taniguchi R, Ono S, Isaji T, Gorecka J, Lee S, Matsubara Y, et al. A mouse model of stenosis distal to an arteriovenous fistula recapitulates human central venous stenosis. JVS Vasc Sci. 2020;1:109-122 pubmed publisher
Gilles G, McCulloch A, Brakebusch C, Herum K. Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction. PLoS ONE. 2020;15:e0241390 pubmed publisher
Gorchs L, Ahmed S, Mayer C, Knauf A, Fernández Moro C, Svensson M, et al. The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity. Sci Rep. 2020;10:17444 pubmed publisher
Suess P, Smith S, Morrissey J. Platelet polyphosphate induces fibroblast chemotaxis and myofibroblast differentiation. J Thromb Haemost. 2020;18:3043-3052 pubmed publisher
Xie B, Lu C, Chen C, Zhou J, Deng Z. miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κB/Inflammatory Signaling Pathway. Mediators Inflamm. 2020;2020:1231243 pubmed publisher
Gonzalez B, Perez Nevarez M, Mirza A, Perez M, Lin Y, Hsu C, et al. Physiologically Relevant Fluid-Induced Oscillatory Shear Stress Stimulation of Mesenchymal Stem Cells Enhances the Engineered Valve Matrix Phenotype. Front Cardiovasc Med. 2020;7:69 pubmed publisher
Davidson S, Efremova M, Riedel A, Mahata B, Pramanik J, Huuhtanen J, et al. Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. Cell Rep. 2020;31:107628 pubmed publisher
Somarathna M, Isayeva Waldrop T, Al Balas A, Guo L, Lee T. A Novel Model of Balloon Angioplasty Injury in Rat Arteriovenous Fistula. J Vasc Res. 2020;57:223-235 pubmed publisher
Polley A, Khanam R, Sengupta A, Chakraborty S. Asporin Reduces Adult Aortic Valve Interstitial Cell Mineralization Induced by Osteogenic Media and Wnt Signaling Manipulation In Vitro. Int J Cell Biol. 2020;2020:2045969 pubmed publisher
Yazawa K, Nakamura F, Masukawa D, Sato S, Hiroshima Y, Yabushita Y, et al. Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic Cancer. Transl Oncol. 2020;13:100746 pubmed publisher
Wang T, Xie S, Luo R, Shi L, Bai P, Wang X, et al. Two novel TSC2 mutations in renal epithelioid angiomyolipoma sensitive to everolimus. Cancer Biol Ther. 2020;21:4-11 pubmed publisher
Martinez L, Robila V, Clark N, Du W, Idowu M, Rutkowski M, et al. Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer. Front Immunol. 2019;10:1942 pubmed publisher
Charbonnier B, Baradaran A, Sato D, Alghamdi O, Zhang Z, Zhang Y, et al. Material-Induced Venosome-Supported Bone Tubes. Adv Sci (Weinh). 2019;6:1900844 pubmed publisher
Lin F, Zeng Z, Song Y, Li L, Wu Z, Zhang X, et al. YBX-1 mediated sorting of miR-133 into hypoxia/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT. Stem Cell Res Ther. 2019;10:263 pubmed publisher
Lin J, Izar B, Wang S, Yapp C, Mei S, Shah P, et al. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. elife. 2018;7: pubmed publisher
Fu X, Khalil H, Kanisicak O, Boyer J, Vagnozzi R, Maliken B, et al. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. J Clin Invest. 2018;128:2127-2143 pubmed publisher
Foo K, Lehtinen M, Leung C, Lian X, Xu J, Keung W, et al. Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther. 2018;26:1644-1659 pubmed publisher
Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, et al. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun. 2016;7:12422 pubmed publisher
MercuŢ R, Ciurea M, Margaritescu C, Popescu S, Crăiţoiu M, Cotoi O, et al. Expression of p53, D2-40 and ?-smooth muscle actin in different histological subtypes of facial basal cell carcinoma. Rom J Morphol Embryol. 2014;55:263-72 pubmed
Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol. 1986;103:2787-96 pubmed
Roholl P, Elbers H, Prinsen I, Claessens J, van Unnik J. Distribution of actin isoforms in sarcomas: an immunohistochemical study. Hum Pathol. 1990;21:1269-74 pubmed
product information
Product Type :
Antibody
Product Name :
Alpha-Smooth Muscle Actin Monoclonal Antibody (1A4), eFluor 570, eBioscience
Catalog # :
41-9760-80
Quantity :
25 ug
Price :
US 171.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 1 ug/mL, Immunohistochemistry (Paraffin): 1 ug/mL, Immunohistochemistry: 1:100
Species :
Human, Mouse, Rat
Clone :
1A4
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actin being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. In particular, smooth muscle actin is an alpha actin that is found in skeletal muscle. Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. Smooth muscle actin is found on smooth muscle vessel walls, gut wall, myometrium, myoepithelial cells in breast and salivary glands. Defects in the smooth muscle actin gene cause aortic aneurysm familial thoracic type 6. Actin isoforms differ slightly in their N-terminus and the sequences of each are perfectly conserved in higher vertebrates. Alpha-smooth muscle actin is abundant in vascular and visceral smooth muscle cells. In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases. Multiple alternatively spliced variants of smooth muscle actin have been identified.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 1 ug/mL, Immunohistochemistry (Paraffin): 1 ug/mL, Immunohistochemistry: 1:100
Aliases :
0610041G09Rik; AAT6; ACT-4; acta2; acta2.L; acta2.S; actin; Actin Alpha 2 Smooth Muscle Aorta; actin alpha 2, smooth muscle; Actin Vascular Smooth Muscle; actin, alpha 2, smooth muscle, aorta; actin, alpha 2, smooth muscle, aorta L homeolog; actin, alpha 2, smooth muscle, aorta S homeolog; actin, alpha, vascular smooth muscle; actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; ACTSA; ACTVS; alpha actin 2; Alpha Cardiac Actin; alpha smooth muscle actin; alpha-actin; Alpha-actin-2; alpha-cardiac actin; alphaSMA; alpha-SM-actin; alpha-smooth muscle actin; Aortic Smooth Muscle; asma; a-sma; cell growth-inhibiting gene 46 protein; GIG46; Growth Inhibiting Gene 46; hypothetical protein LOC515610; LOW QUALITY PROTEIN: actin, aortic smooth muscle; mymy5; SM actin; sma; SMactin; sm-actin; SMalphaA; smooth muscle; smooth muscle alpha-actin; vascular smooth muscle alpha-actin; wu:fb63d03; XELAEV_18034370mg
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA