Connexin 45 Monoclonal Antibody (5C7G1) | Invitrogen 41-5800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Connexin 45 Monoclonal Antibody (5C7G1)

catalog :

41-5800

quantity :

100 µg

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5C7G1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:2000; loading ...; fig 2d	Guo R, Si R, Scott B, Makino A. Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells. Am J Physiol Cell Physiol. 2017;312:C398-C406 pubmed publisher
immunohistochemistry; mouse; 1:400	de Andrade G, Kunzelman L, Merrill M, Fuerst P. Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. Mol Vis. 2014;20:1422-33 pubmed
	Cooler S, Schwartz G. An offset ON-OFF receptive field is created by gap junctions between distinct types of retinal ganglion cells. Nat Neurosci. 2021;24:105-115 pubmed publisher
	Dierks A, Bader A, Lehrich T, Ngezahayo A. Stimulation of the A2B Adenosine Receptor Subtype Enhances Connexin26 Hemichannel Activity in Small Airway Epithelial Cells. Cell Physiol Biochem. 2019;53:606-622 pubmed publisher
	Jacoby J, Nath A, Jessen Z, Schwartz G. A Self-Regulating Gap Junction Network of Amacrine Cells Controls Nitric Oxide Release in the Retina. Neuron. 2018;100:1149-1162.e5 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Connexin 45 Monoclonal Antibody (5C7G1)

Catalog # :

41-5800

Quantity :

100 µg

Price :

US 450

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 2 µg/mL

Species :

Human, Mouse

Clone :

5C7G1

Isotype :

IgG1

Storage :

-20°C

Description :

Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell closely packed transmembrane channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. Connexins are designated by their molecular mass. Another system of nomenclature divides gap junction proteins into 2 categories, alpha and beta, according to sequence similarities at the nucleotide and amino acid levels. For example, CX43 is designated alpha-1 gap junction protein, whereas CX32 and CX26 are called beta-1 and beta-2 gap junction proteins, respectively. This nomenclature emphasizes that CX32 and CX26 are more homologous to each other than either of them is to CX43. Connexins have four transmembrane, three intracellular, and two extracellular regions. Different tissues express different connexins, though tissue specificities overlap, and a given tissue or cell can express several different connexins. Developmental regulation of at least some of the connexin genes has been found. Embryo implantation is regulated in part by temporally changing patterns of expression of connexins in the embryo and the maternal decidua.

Immunogen :

Peptide corresponding to amino acid residues from the C-terminal region of mouse connexin 45 protein (accession # P28229, NP_032148.1), which is 100% homologous with rat and 93% homologous with human, rhesus monkey, swine and canine.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 2 µg/mL

Aliases :

C130009G16Rik; Cnx45; connexin 45; connexin-45; CTC-296K1.4; CX45; Cxn-45; Gap junction alpha-7 protein; gap junction channel protein connexin 45; gap junction gamma-1 protein; gap junction membrane channel protein alpha 7; gap junction protein gamma 1; gap junction protein, gamma 1; gap junction protein, gamma 1, 45kDa; Gja7; Gja-7; GJC1

more info or order :

Invitrogen product webpage