Ninein Monoclonal Antibody (79.160-7) | Invitrogen 41-3400 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ninein Monoclonal Antibody (79.160-7)

catalog :

41-3400

quantity :

100 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

79.160-7

reactivity :

human, bovine

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Mikulenkova E, Neradil J, Vymazal O, Skoda J, Veselska R. NANOG/NANOGP8 Localizes at the Centrosome and is Spatiotemporally Associated with Centriole Maturation. Cells. 2020;9: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Ninein Monoclonal Antibody (79.160-7)

Catalog # :

41-3400

Quantity :

100 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Human, Non-human primate

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 5 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Bovine, Human, Non-human primate

Clone :

79.160-7

Isotype :

IgG2a

Storage :

-20 C

Description :

Ninein is a component of subdistal appendages of the mother centriole, localized specifically in the pericentriolar matrix of the centrosome. It may be involved in microtubule minus-end capping, centriole positioning, and protein anchoring. Recent studies have shown that the microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function. At least five human ninein isoforms with divergent C-terminal domains and two mouse isoforms have been reported. Data indicates that the combined action of domains (C-terminal and N-terminal) might, in the absence of coiled coil region, be sufficient to localize ninein to the mother centriole. Microinjection of antibodies against ninein into metaphase HeLa cells can disrupt the reformation of tubular conformation of proteins within the centrosome following cell division, and consequently lead to dispersal of centrosomal material throughout the cytosol. MTOC (microtubule organizing center) function can be disrupted when anti-ninein antibodies are injected into postmitotic cells. Antibodies against ninein are present in sera from patients with autoimmune diseases that develop autoantibodies to centrosomal proteins.

Immunogen :

Synthetic peptide derived from an internal region of the human ninein protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 5 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

3110068G20Rik; AI385615; AU024711; glycogen synthase kinase 3 beta-interacting protein; GSK3B-interacting protein; hNinein; KIAA1565; mKIAA1565; Nin; Ninein; ninein (GSK3B interacting protein); ninein centrosomal protein; SCKL7