CEP170 Monoclonal Antibody (72-413-1) | Invitrogen 41-3200 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CEP170 Monoclonal Antibody (72-413-1)

catalog :

41-3200

quantity :

100 µg

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

72-413-1

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; fig 2a	Kanie T, Abbott K, Mooney N, Plowey E, Demeter J, JACKSON P. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017;42:22-36.e12 pubmed publisher
immunocytochemistry; human; 1:50; fig 1	Mukhopadhyay A, Sehgal L, Bose A, Gulvady A, Senapati P, Thorat R, et al. 14-3-3? Prevents Centrosome Amplification and Neoplastic Progression. Sci Rep. 2016;6:26580 pubmed publisher
immunocytochemistry; human; 1:500; fig s2	Guen V, Gamble C, Perez D, Bourassa S, Zappel H, Gartner J, et al. STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Cell Cycle. 2016;15:678-88 pubmed publisher
immunoprecipitation; human; fig 5 immunocytochemistry; human; 1:100; fig 4 western blot; human; 1:1000; fig 5	Pillai S, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S. Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nat Commun. 2015;6:10072 pubmed publisher
western blot; human; fig 1	Fuchs M, Luthold C, Guilbert S, Varlet A, Lambert H, Jetté A, et al. A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis. PLoS Genet. 2015;11:e1005582 pubmed publisher
immunocytochemistry; human; 1:500	Douthwright S, Sluder G. Link between DNA damage and centriole disengagement/reduplication in untransformed human cells. J Cell Physiol. 2014;229:1427-36 pubmed publisher
	Kanie T, Ng R, Abbott K, Pongs O, Jackson P. Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages. bioRxiv. 2023;: pubmed publisher
	Chen F, Wu J, Iwanski M, Jurriens D, Sandron A, Pasolli M, et al. Self-assembly of pericentriolar material in interphase cells lacking centrioles. elife. 2022;11: pubmed publisher
	Ho J, Cunningham T, Manara P, Coughlin C, Arumov A, Roberts E, et al. Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome. Cell Rep. 2021;37:109806 pubmed publisher
	Hilgendorf K, Johnson C, Mezger A, Rice S, Norris A, Demeter J, et al. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019;179:1289-1305.e21 pubmed publisher
	Kashihara H, Chiba S, Kanno S, Suzuki K, Yano T, Tsukita S. Cep128 associates with Odf2 to form the subdistal appendage of the centriole. Genes Cells. 2019;24:231-243 pubmed publisher
	Denu R, Shabbir M, Nihal M, Singh C, Longley B, Burkard M, et al. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018;16:517-527 pubmed publisher
	Gimpel P, Lee Y, Sobota R, Calvi A, Koullourou V, Patel R, et al. Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells. Curr Biol. 2017;27:2999-3009.e9 pubmed publisher
	Kwun H, Wendzicki J, Shuda Y, Moore P, Chang Y. Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting. Oncogene. 2017;36:6784-6792 pubmed publisher
	Barbiero I, Valente D, Chandola C, Magi F, Bergo A, Monteonofrio L, et al. CDKL5 localizes at the centrosome and midbody and is required for faithful cell division. Sci Rep. 2017;7:6228 pubmed publisher
	Grimm Günter E, Milbrandt M, Merkl B, Paulsson M, Plomann M. PACSIN proteins bind tubulin and promote microtubule assembly. Exp Cell Res. 2008;314:1991-2003 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CEP170 Monoclonal Antibody (72-413-1)

Catalog # :

41-3200

Quantity :

100 µg

Price :

US 450

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

72-413-1

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.

Immunogen :

Recombinant protein derived from the N-terminal region of the human Cep170 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

4933426L22Rik; A330004A13Rik; AI195353; centrosomal protein 170; centrosomal protein 170kDa; centrosomal protein of 170 kDa; CEP170; FAM68A; KAB; KARP-1-binding protein; KARP1-binding protein; KIAA0470; XRCC5 binding protein

more info or order :

Invitrogen product webpage