RUNX2 Monoclonal Antibody (ZR002) | Invitrogen 41-1400 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RUNX2 Monoclonal Antibody (ZR002)

catalog :

41-1400

quantity :

100 µg

price :

US 430.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ZR002

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:400; fig 2f ELISA; human; 1:200; loading ...; tbl 2	Srikanth L, Sunitha M, Kumar P, Chandrasekhar C, Vengamma B, Sarma P. Gel based in vitro 3D model exploring the osteocytic potentiality of human CD34+ stem cells. Mol Biol Rep. 2016;43:1233-1242 pubmed
blocking or activating experiments; human; 1 ug/ml	Pilia M, Guda T, Shiels S, Appleford M. Influence of substrate curvature on osteoblast orientation and extracellular matrix deposition. J Biol Eng. 2013;7:23 pubmed publisher
	Baniwal S, Little G, Chimge N, Frenkel B. Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation. J Cell Physiol. 2012;227:2276-82 pubmed publisher

product information

Product Type :

Antibody

Product Name :

RUNX2 Monoclonal Antibody (ZR002)

Catalog # :

41-1400

Quantity :

100 µg

Price :

US 430.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

ZR002

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

RUNX2, a nuclear protein, is a member of the RUNX family of transcription factors and has an Runt DNA-binding domain. It is essential for membranous and endochondral bone formation. It not only regulates osteoblastic differentiation and skeletal morphogenesis but also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer and with more affinity, as a subunit of a heterodimeric complex. It plays a critical role in increasing TGFBR1 expression by osteoblasts and functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. Mutations lead to disorders in bone development like cleidocranial dysplasia (CCD).

Immunogen :

Synthetic peptide derived from the C-terminal region of the human and mouse Runx2 proteins

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Aliases :

Acute myeloid leukemia 3 protein; AKV core binding factor; Aml3; AML-3; Cbf; Cbfa1; Cbfa-1; CBF-alpha-1; CCD; CCD1; CLCD; core binding factor alpha 1; core binding factor alpha 1 subunit; core-binding factor subunit alpha-1; core-binding factor, runt domain, alpha subunit 1; LOW QUALITY PROTEIN: runt-related transcription factor 2; LS3; Oncogene AML-3; Osf2; OSF-2; osteoblast-specific transcription factor 2; PEA2aA; PEA2-alpha A; PEBP2 alpha A; PEBP2A; Pebp2a1; PEBP2aA; PEBP2-alpha A; Pebpa2a; Polyomavirus enhancer-binding protein 2 alpha A subunit; runt domain, alpha subunit 1; runt related transcription factor 2; runt-related transcription factor 2; RUNX 2; RUNX family transcription factor 2; Runx2; RUNX-2; SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; transcription factor RUNX2; transcription factor RUNX2/CBFA1

more info or order :

Invitrogen product webpage