ING4 Polyclonal Antibody | Invitrogen 40-7700 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ING4 Polyclonal Antibody

catalog :

40-7700

quantity :

100 µg

price :

449 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 4

Reference
You Q, Li H, Liu Y, Xu Y, Miao S, Yao G, et al. MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling. Oncol Lett. 2018;16:2326-2334 pubmed publisher
Sica V, Bravo San Pedro J, Chen G, Mariño G, Lachkar S, Izzo V, et al. Inhibitor of growth protein 4 interacts with Beclin 1 and represses autophagy. Oncotarget. 2017;8:89527-89538 pubmed publisher
Ren Y, Zhao S, Chen H, Fu Y, Zhao B. Association between the expression of inhibitor of growth family member 4 and the progression of clear cell renal carcinoma. Oncol Lett. 2017;14:2453-2457 pubmed publisher
Wang Y, Wang T, Han Y, Wu H, Zhao W, Tong D, et al. Reduced ING4 Expression Is Associated with the Malignancy of Human Bladder. Urol Int. 2015;94:464-71 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ING4 Polyclonal Antibody

Catalog # :

40-7700

Quantity :

100 µg

Price :

449 USD

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: Assay Dependent

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20°C

Description :

The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors. All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure. ING proteins have been shown to form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including growth arrest, DNA repair, gene transcription, apoptosis, and senescence. The candidate tumor suppressor ING4 has a role in brain tumor pathogenesis, and is involved in regulating tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, and ING4 reduction correlates with progression from lower to higher grades of tumors. ING4 physically interacts with the p65 (RelA) subunit of NF-kB and represses transcription of NF-kB responsive genes. Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10-20% of human breast cancer cell lines and tumors.

Immunogen :

Synthetic peptide derived from the internal region of the human, mouse and rat ING4 proteins

Format :

Liquid

Applications w/Dilutions :

Western Blot: Assay Dependent

Aliases :

brain my036 protein; candidate tumor suppressor p33 ING1 homolog; D6Wsu147e; D6Xrf92; ING1-like protein; Ing4; inhibitor of growth family member 4; inhibitor of growth family, member 4; inhibitor of growth protein 4; My036; p29ING4