DISC1 Polyclonal Antibody | Invitrogen 40-6800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DISC1 Polyclonal Antibody

catalog :

40-6800

quantity :

100 µg

price :

US 450

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 7	Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
	Samard x17e ija B, Jukovi x107 M, Zaharija B, Renner x, Palkovits M, Bradshaw N. Co-Aggregation and Parallel Aggregation of Specific Proteins in Major Mental Illness. Cells. 2023;12: pubmed publisher
	Xu X, Song L, Hanganu Opatz I. Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal-Hippocampal Coupling and the Cognitive Performance Throughout Development. Cereb Cortex. 2021;31:1240-1258 pubmed publisher
	Xu X, Chini M, Bitzenhofer S, Hanganu Opatz I. Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development. J Neurosci. 2019;39:1222-1235 pubmed publisher

product information

Product Type :

Antibody

Product Name :

DISC1 Polyclonal Antibody

Catalog # :

40-6800

Quantity :

100 µg

Price :

US 450

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1-3 µg/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20°C

Description :

DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system, and is involved in neuronal functions that are dependent upon proper cytoskeletal regulation, including neuronal migration, neurite architecture and intracellular transport. Regions of the brain which express DISC1 include the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum and paraventricular hypothalamus, and loss of DISC1 function results in differences in structural organization.The DISC1 gene locus is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2, beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Immunogen :

Synthetic peptide derived from the C-terminal region of the mouse DISC1 (disrupted in schizophrenia 1) protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1-3 µg/mL

Aliases :

C1orf136; DISC1; disrupted in schizophrenia 1; disrupted in schizophrenia 1 homolog; Disrupted in schizophrenia 1 protein; KIAA0457; RP4-730B13.1; SCZD9

more info or order :

Invitrogen product webpage