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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Metadherin Polyclonal Antibody
catalog :
40-6400
quantity :
100 µg
price :
US 480.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 4
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 4a
Zhou C, Wang C, Yu A, Wang Q, Zhan M, Tang J, et al. MiR-630 suppresses breast cancer progression by targeting metadherin. Oncotarget. 2016;7:1288-99 pubmed publisher
Lin L, Lai P, Chen Y, Chen C. Expression of astrocyte-elevated gene-1 indicates prognostic value of fluoropyrimidine-based adjuvant chemotherapy in resectable stage III colorectal cancer. Pathol Int. 2021;71:752-764 pubmed publisher
Cao D, Zhu H, Zhao Q, Huang J, Zhou C, He J, et al. MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells. Biol Res. 2020;53:43 pubmed publisher
Chen C, Chen Y, Chen J, Chen K, Ho C, Shih J, et al. Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression. Oncotarget. 2017;8:61901-61916 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Metadherin Polyclonal Antibody
Catalog # :
40-6400
Quantity :
100 µg
Price :
US 480.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
Immunocytochemistry: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1-2 µg/mL
Species :
Human, Mouse
Isotype :
IgG
Storage :
-20°C
Description :
Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
Immunogen :
Raised against the C-term of human Metadherin.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1-2 µg/mL
Aliases :
2610103J23Rik; 3D3; 3D3/Lyric; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; AV353288; D8Bwg1112e; LYRIC; LYRIC/ MTDH; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; MTDH; Protein LYRIC
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA