JPH2 Polyclonal Antibody | Invitrogen 40-5300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

JPH2 Polyclonal Antibody

catalog :

40-5300

quantity :

100 µg

price :

US 430.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig s2a immunohistochemistry; human; loading ...; fig s2c	Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018;362: pubmed publisher
immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 1a immunocytochemistry; mouse; 1:50; loading ...; fig 2a	Munro M, Jayasinghe I, Wang Q, Quick A, Wang W, Baddeley D, et al. Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. J Cell Sci. 2016;129:4388-4398 pubmed
	Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel E, et al. Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. Biochem J. 2021;478:3539-3553 pubmed publisher
	Lyu Y, Verma V, Lee Y, Taleb I, Badolia R, Shankar T, et al. Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart. NPJ Aging Mech Dis. 2021;7:16 pubmed publisher
	Fiegle D, Schober M, Dittrich S, Cesnjevar R, Klingel K, Volk T, et al. Severe T-System Remodeling in Pediatric Viral Myocarditis. Front Cardiovasc Med. 2020;7:624776 pubmed publisher
	Feyen D, McKeithan W, Bruyneel A, Spiering S, Hörmann L, Ulmer B, et al. Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Rep. 2020;32:107925 pubmed publisher
	Pritchard H, Griffin C, Yamasaki E, Thakore P, Lane C, Greenstein A, et al. Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility. Proc Natl Acad Sci U S A. 2019;116:21874-21881 pubmed publisher
	Kong C, Bryant S, Watson J, Roth D, Patel H, Cannell M, et al. Cardiac-specific overexpression of caveolin-3 preserves t-tubular ICa during heart failure in mice. Exp Physiol. 2019;104:654-666 pubmed publisher
	Bryant S, Kong C, Watson J, Gadeberg H, Roth D, Patel H, et al. Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular ICa density in mouse ventricular myocytes. Am J Physiol Heart Circ Physiol. 2018;315:H1101-H1111 pubmed publisher
	Bryant S, Kong C, Watson J, Gadeberg H, James A, Cannell M, et al. Caveolin 3-dependent loss of t-tubular ICa during hypertrophy and heart failure in mice. Exp Physiol. 2018;103:652-665 pubmed publisher
	Hu L, Ackermann M, Hecker P, Prosser B, King B, O Connell K, et al. Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. Sci Adv. 2017;3:e1603081 pubmed publisher

product information

Product Type :

Antibody

Product Name :

JPH2 Polyclonal Antibody

Catalog # :

40-5300

Quantity :

100 µg

Price :

US 430.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Mouse

Applications :

Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Western Blot: 2-3 µg/mL

Species :

Mouse

Isotype :

IgG

Storage :

-20°C

Description :

This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen :

Synthetic peptide derived from the C-terminal region of the mouse junctophilin-2 (JPH2, JP-2, junctophilin type 2) protein, which differs from rat by one non-conservative amino acid

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Western Blot: 2-3 µg/mL

Aliases :

1110002E14Rik; CMH17; Jp2; JP-2; JP2NT; JPH2; jph2 {ECO:0000312; junctophilin 2; junctophilin type 2; Junctophilin-2; Junctophilin-2 N-terminal fragment; RGD:1305196}

more info or order :

Invitrogen product webpage