product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
ZO-1 Polyclonal Antibody
catalog :
40-2200
quantity :
100 µg
price :
US 520.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, chicken, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 275
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; zebrafish ; 1:150; loading ...; fig 9a
Li Y, Wang C, Zhang L, Chen B, Mo Y, Zhang J. Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids Barriers CNS. 2022;19:40 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s8a
Zhao Q, Dai W, Chen H, Jacobs R, Zlokovic B, Lund B, et al. Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation. Proc Natl Acad Sci U S A. 2022;119:e2113310119 pubmed publisher
  • immunocytochemistry; rat; 1:200; fig 3m
  • immunocytochemistry; human; 1:200; fig 3e
Li J, Qiu C, Wei Y, Yuan W, Liu J, Cui W, et al. Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration. Front Cell Dev Biol. 2021;9:737242 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 4a
  • western blot; mouse; 1:1000; fig 4e
Nikolakopoulou A, Wang Y, Ma Q, Sagare A, Montagne A, Huuskonen M, et al. Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. J Exp Med. 2021;218: pubmed publisher
  • immunocytochemistry; human; 1:200; fig 3c
Yang C, Eleftheriadou M, Kelaini S, Morrison T, González M, Caines R, et al. Targeting QKI-7 in vivo restores endothelial cell function in diabetes. Nat Commun. 2020;11:3812 pubmed publisher
  • immunocytochemistry; mouse; 1:400; loading ...; fig 4a
Hou M, Han J, Li G, Kwon M, Jiang J, Emani S, et al. Multipotency of mouse trophoblast stem cells. Stem Cell Res Ther. 2020;11:55 pubmed publisher
  • western blot; human; loading ...; fig 2b
Kramer M, Markart P, Drakopanagiotakis F, Mamazhakypov A, Schaefer L, Didiasova M, et al. Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system. Cell Signal. 2020;65:109432 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s3f
Diéguez Hurtado R, Kato K, Giaimo B, Nieminen Kelhä M, Arf H, Ferrante F, et al. Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun. 2019;10:2817 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2s2
Wang Y, Sabbagh M, Gu X, Rattner A, Williams J, Nathans J. Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; loading ...; fig s7e
Souma T, Thomson B, Heinen S, Carota I, Yamaguchi S, Onay T, et al. Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A. 2018;115:1298-1303 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1f
Pelz L, Purfürst B, Rathjen F. The cell adhesion molecule BT-IgSF is essential for a functional blood-testis barrier and male fertility in mice. J Biol Chem. 2017;292:21490-21503 pubmed publisher
  • immunocytochemistry; human; fig 6b
Hazim R, Karumbayaram S, Jiang M, Dimashkie A, Lopes V, Li D, et al. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2017;8:217 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3h
Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher
  • immunocytochemistry; human; fig 1a
  • western blot; human; fig 1b
Wilkinson E, Sidaway J, Cross M. Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells. J Cell Physiol. 2018;233:186-200 pubmed publisher
  • immunohistochemistry; human; 1:200; fig 5l
Benedicto I, Lehmann G, Ginsberg M, Nolan D, Bareja R, Elemento O, et al. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors. Nat Commun. 2017;8:15374 pubmed publisher
  • immunocytochemistry; mouse; fig 6e
Li Y, Urban A, Midura D, Simon H, Wang Q. Proteomic characterization of epicardial-myocardial signaling reveals novel regulatory networks including a role for NF-κB in epicardial EMT. PLoS ONE. 2017;12:e0174563 pubmed publisher
  • immunohistochemistry - frozen section; human; fig 1e
Miyashita H, Niwano H, Yoshida S, Hatou S, Inagaki E, Tsubota K, et al. Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model. Sci Rep. 2017;7:43557 pubmed publisher
  • immunocytochemistry; mouse; fig 2c
  • western blot; mouse; fig 2c
Prasad S, Sajja R, Kaisar M, Park J, Villalba H, Liles T, et al. Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity. Redox Biol. 2017;12:58-69 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...
Zhang W, Li H, Ogando D, Li S, Feng M, Price F, et al. Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium. EBioMedicine. 2017;16:292-301 pubmed publisher
  • immunocytochemistry; human; 500 ug/ml; loading ...; fig 4
Varadi J, Harazin A, Fenyvesi F, Réti Nagy K, Gogolak P, Vámosi G, et al. Alpha-Melanocyte Stimulating Hormone Protects against Cytokine-Induced Barrier Damage in Caco-2 Intestinal Epithelial Monolayers. PLoS ONE. 2017;12:e0170537 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s6a
Bordeleau F, Mason B, Lollis E, Mazzola M, Zanotelli M, Somasegar S, et al. Matrix stiffening promotes a tumor vasculature phenotype. Proc Natl Acad Sci U S A. 2017;114:492-497 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3a
Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, et al. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017;144:201-210 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 4f
He Z, Forest F, Bernard A, Gauthier A, Montard R, Peoc h M, et al. Cutting and Decellularization of Multiple Corneal Stromal Lamellae for the Bioengineering of Endothelial Grafts. Invest Ophthalmol Vis Sci. 2016;57:6639-6651 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4
Hurtado Alvarado G, Dominguez Salazar E, Velazquez Moctezuma J, Gómez González B. A2A Adenosine Receptor Antagonism Reverts the Blood-Brain Barrier Dysfunction Induced by Sleep Restriction. PLoS ONE. 2016;11:e0167236 pubmed publisher
  • western blot; human; fig 1a
Che D, Zhou T, Lan Y, Xie J, Gong H, Li C, et al. High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells. Int J Mol Med. 2016;38:1815-1822 pubmed publisher
  • western blot; rat; 1:200; loading ...; fig 6c
Huang L, Cao W, Deng Y, Zhu G, Han Y, Zeng H. Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes. BMC Neurosci. 2016;17:64 pubmed
  • immunocytochemistry; mouse; 1:200; fig 2f
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, et al. An in vitro model of murine middle ear epithelium. Dis Model Mech. 2016;9:1405-1417 pubmed
  • western blot; mouse; fig 3
Xiong J, Zhou M, Wang Y, Chen L, Xu W, Wang Y, et al. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep. 2016;6:34079 pubmed publisher
  • western blot; human; loading ...; fig 9a
Shang V, Kendall D, Roberts R. ?9-Tetrahydrocannabinol reverses TNF?-induced increase in airway epithelial cell permeability through CB2 receptors. Biochem Pharmacol. 2016;120:63-71 pubmed publisher
  • immunocytochemistry; human; 2.5 ug/ml; loading ...; fig 3d
Qian Y, Li C, Jiang A, Ge S, Gu P, Fan X, et al. HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability. J Biol Chem. 2016;291:22977-22987 pubmed
  • immunohistochemistry - paraffin section; dogs; 1:200; loading ...; fig 4c
  • western blot; dogs; 1:1000; loading ...; fig 3f
Ahn C, Shin D, Lee D, Kang S, Seok J, Kang H, et al. Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Mol Med Rep. 2016;14:3697-703 pubmed publisher
  • immunocytochemistry; human; fig 1
Soayfane Z, Tercé F, Cantiello M, Robenek H, Nauze M, Bézirard V, et al. Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane. Nutr Metab (Lond). 2016;13:48 pubmed publisher
  • immunohistochemistry; mouse; fig 3e
  • western blot; mouse; fig 3a
Zhang Z, Yan J, Shi H. Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke. Neurobiol Dis. 2016;95:82-92 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 3b
Dauleh S, Santeramo I, Fielding C, Ward K, Herrmann A, Murray P, et al. Characterisation of Cultured Mesothelial Cells Derived from the Murine Adult Omentum. PLoS ONE. 2016;11:e0158997 pubmed publisher
  • immunohistochemistry; human; fig 3A
He Z, Forest F, Gain P, Rageade D, Bernard A, Acquart S, et al. 3D map of the human corneal endothelial cell. Sci Rep. 2016;6:29047 pubmed publisher
  • western blot; human; fig 3b
Guo Y, Wang L, Li B, Xu H, Yang J, Zheng L, et al. Wnt/?-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. Oncotarget. 2016;7:42513-42526 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Wang E, Geng A, Maniar A, Mui B, Gong X. Connexin 50 Regulates Surface Ball-and-Socket Structures and Fiber Cell Organization. Invest Ophthalmol Vis Sci. 2016;57:3039-46 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Wang X, Fan F, Cao Q. Modified Pulsatilla decoction attenuates oxazolone-induced colitis in mice through suppression of inflammation and epithelial barrier disruption. Mol Med Rep. 2016;14:1173-9 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Lee S, Kim H, Kim K, Lee H, Lee S, Lee D. Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon. Sci Rep. 2016;6:26923 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 4
  • western blot; rat; 1:500; fig 2
Xu S, Xue X, You K, Fu J. Caveolin-1 regulates the expression of tight junction proteins during hyperoxia-induced pulmonary epithelial barrier breakdown. Respir Res. 2016;17:50 pubmed publisher
  • immunocytochemistry; mouse; fig 2
Ramesh S, Singh A, Cibi D, Hausenloy D, Singh M. In Vitro Culture of Epicardial Cells From Mouse Embryonic Heart. J Vis Exp. 2016;: pubmed publisher
  • immunohistochemistry; mouse; fig s6
Vorvis C, Hatziapostolou M, Mahurkar Joshi S, Koutsioumpa M, Williams J, Donahue T, et al. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2016;310:G1124-37 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 1
Ehlen L, Tödtmann J, Specht S, Kallies R, Papies J, Muller M, et al. Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses. Virol J. 2016;13:74 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 2
Iwai Takekoshi L, Ramos A, Schaler A, Weinreb S, Blazeski R, Mason C. Retinal pigment epithelial integrity is compromised in the developing albino mouse retina. J Comp Neurol. 2016;524:3696-3716 pubmed publisher
  • immunocytochemistry; mouse; 1:50; fig 2
Waisbourd Zinman O, Koh H, Tsai S, Lavrut P, Dang C, Zhao X, et al. The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17. Hepatology. 2016;64:880-93 pubmed publisher
  • western blot; rat; fig 6
Liu Z, Wang S, Liu J, Wang F, Liu Y, Zhao Y. Leukocyte Infiltration Triggers Seizure Recurrence in a Rat Model of Temporal Lobe Epilepsy. Inflammation. 2016;39:1090-8 pubmed publisher
  • immunocytochemistry; mouse; fig 2
Trembley M, Velasquez L, Small E. Epicardial Outgrowth Culture Assay and Ex Vivo Assessment of Epicardial-derived Cell Migration. J Vis Exp. 2016;: pubmed publisher
  • immunohistochemistry; chicken; 1:100; fig 1
Nitzan E, Avraham O, Kahane N, Ofek S, Kumar D, Kalcheim C. Dynamics of BMP and Hes1/Hairy1 signaling in the dorsal neural tube underlies the transition from neural crest to definitive roof plate. BMC Biol. 2016;14:23 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 6
Wu W, Zeng Y, Li Z, Li Q, Xu H, Yin Z. Features specific to retinal pigment epithelium cells derived from three-dimensional human embryonic stem cell cultures - a new donor for cell therapy. Oncotarget. 2016;7:22819-33 pubmed publisher
  • immunohistochemistry; rat; 1:100; fig s1
Viringipurampeer I, Metcalfe A, Bashar A, Sivak O, Yanai A, Mohammadi Z, et al. NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration. Hum Mol Genet. 2016;25:1501-16 pubmed publisher
  • western blot; human; 1:4000; fig 1
Bassey Archibong B, Kwiecien J, Milosavljevic S, Hallett R, Rayner L, Erb M, et al. Kaiso depletion attenuates transforming growth factor-? signaling and metastatic activity of triple-negative breast cancer cells. Oncogenesis. 2016;5:e208 pubmed publisher
  • immunocytochemistry; mouse; 1:200; tbl 1
Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez V, et al. GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells. Endocrinology. 2016;157:2416-31 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s4c
Escobedo N, Proulx S, Karaman S, Dillard M, Johnson N, Detmar M, et al. Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice. JCI Insight. 2016;1: pubmed
  • immunohistochemistry; mouse; 1:200; fig 5
  • immunocytochemistry; human; 1:200; fig 6
Ibrahim A, Mander S, Hussein K, Elsherbiny N, Smith S, Al Shabrawey M, et al. Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration. Oncotarget. 2016;7:8532-45 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Li H, Ruberu K, Karl T, Garner B. Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. PLoS ONE. 2016;11:e0148238 pubmed publisher
  • western blot; human; 1:1000; fig 7
Shang V, O Sullivan S, Kendall D, Roberts R. The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite. Pharmacol Res. 2016;105:152-63 pubmed publisher
  • immunohistochemistry; mouse; 3:1000; fig 1
Loebel D, Plageman T, Tang T, Jones V, Muccioli M, Tam P. Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction. Biol Open. 2016;5:130-9 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 2
Stebbins M, Wilson H, Canfield S, Qian T, Palecek S, Shusta E. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells. Methods. 2016;101:93-102 pubmed publisher
  • western blot; mouse; fig 1d
Nagaoka K, Fujii K, Zhang H, Usuda K, Watanabe G, Ivshina M, et al. CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis. Oncogene. 2016;35:2893-901 pubmed publisher
Zhang W, Tian Z, Qi X, Chen P, Yang Q, Guan Q, et al. Switching from high-fat diet to normal diet ameliorate BTB integrity and improve fertility potential in obese male mice. Sci Rep. 2023;13:14152 pubmed publisher
Wang J, Rattner A, Nathans J. Bacterial meningitis in the early postnatal mouse studied at single-cell resolution. elife. 2023;12: pubmed publisher
Cossec J, Traboulsi T, Sart S, Loe Mie Y, Guthmann M, Hendriks I, et al. Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures. Cell Rep. 2023;42:112380 pubmed publisher
. Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes. J Pharmacol Exp Ther. 2023;385:135-145 pubmed publisher
Bebelman M, Bovyn M, Mayer C, Delpierre J, Naumann R, Martins N, et al. Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure. J Cell Biol. 2023;222: pubmed publisher
Branca J, Boninsegna M, Morucci G, Carrino D, Nicoletti C, Paternostro F, et al. Morphological and Functional Effects of Ultrasound on Blood-Brain Barrier Transitory Opening: An In Vitro Study on Rat Brain Endothelial Cells. Cells. 2023;12: pubmed publisher
Zhou Y, Zhang Z, Sun Y, Zhou D, Zhao Y, Li J, et al. Liangxue Tongyu Prescription Alleviates Brain Damage in Acute Intracerebral Hemorrhage Rats by Regulating Intestinal Mucosal Barrier Function. Evid Based Complement Alternat Med. 2022;2022:2197763 pubmed publisher
Kwon Y, Banskota S, Wang H, Rossi L, Grondin J, Syed S, et al. Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nat Commun. 2022;13:7617 pubmed publisher
Caneparo C, Chabaud S, Fradette J, Bolduc S. Engineered human organ-specific urethra as a functional substitute. Sci Rep. 2022;12:21346 pubmed publisher
Raghavan S, Brishti M, COLLIER D, Leo M. Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function. Front Physiol. 2022;13:1049698 pubmed publisher
Zhou R, Li J, Wang R, Chen Z, Zhou F. Moderate systemic therapeutic hypothermia is insufficient to protect blood-spinal cord barrier in spinal cord injury. Front Neurol. 2022;13:1041099 pubmed publisher
Gerstmann K, Kindbeiter K, Telley L, Bozon M, Reynaud F, Th xe9 oulle E, et al. A balance of noncanonical Semaphorin signaling from the cerebrospinal fluid regulates apical cell dynamics during corticogenesis. Sci Adv. 2022;8:eabo4552 pubmed publisher
Zhang X, Qiu J, Huang F, Shan K, Zhang C. Type 2 Diabetes Mellitus Makes Corneal Endothelial Cells Vulnerable to Ultraviolet A-Induced Oxidative Damage Via Decreased DJ-1/Nrf2/NQO1 Pathway. Invest Ophthalmol Vis Sci. 2022;63:25 pubmed publisher
Maurizi E, Martella D, Schiroli D, Merra A, Mustfa S, Pellegrini G, et al. Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium. Adv Sci (Weinh). 2022;9:e2203257 pubmed publisher
Park J, Gabel A, Kassir P, Kang L, Chowdhary P, Osei Ntansah A, et al. N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. elife. 2022;11: pubmed publisher
Tsou H, Wang P, Ting T, Ping Y, Liu T, Cheng H, et al. Effect of heated tobacco products and traditional cigarettes on pulmonary toxicity and SARS-CoV-2-induced lung injury. Toxicology. 2022;479:153318 pubmed publisher
Sifat A, Archie S, Nozohouri S, Villalba H, Zhang Y, Sharma S, et al. Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome. Fluids Barriers CNS. 2022;19:74 pubmed publisher
Zhu Y, Chew K, Wu M, Karawita A, McCallum G, Steele L, et al. Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells. PLoS Biol. 2022;20:e3001728 pubmed publisher
Faynus M, Bailey J, Pennington B, Katsura M, Proctor D, Yeh A, et al. Microcarrier-Based Culture of Human Pluripotent Stem-Cell-Derived Retinal Pigmented Epithelium. Bioengineering (Basel). 2022;9: pubmed publisher
Hazim R, Paniagua A, Tang L, Yang K, Kim K, Stiles L, et al. Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium. J Biol Chem. 2022;298:102286 pubmed publisher
Richards M, Nwadozi E, Pal S, Martinsson P, Kaakinen M, Gloger M, et al. Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner. elife. 2022;11: pubmed publisher
Zolotoff C, Puech C, Roche F, Perek N. Effects of intermittent hypoxia with thrombin in an in vitro model of human brain endothelial cells and their impact on PAR-1/PAR-3 cleavage. Sci Rep. 2022;12:12305 pubmed publisher
Gomes de Almeida P, Rifes P, Martins Jesus A, Pinheiro G, Andrade R, Thorsteinsd xf3 ttir S. Cell-Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis. Cells. 2022;11: pubmed publisher
Molins Guti xe9 rrez G, Martorell J, Salazar Martín A, Balcells M. A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress. Methods Mol Biol. 2022;2492:175-190 pubmed publisher
B xe9 renger Currias N, Mircea M, Adegeest E, van den Berg P, Feliksik M, Hochane M, et al. A gastruloid model of the interaction between embryonic and extra-embryonic cell types. J Tissue Eng. 2022;13:20417314221103042 pubmed publisher
Chou H, Cheng C, Yang C, Lin T, Liu Y, Tan T, et al. DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction. J Biomed Sci. 2022;29:40 pubmed publisher
Meena A, Shukla P, Bell B, Giorgianni F, Caires R, Fernández Peña C, et al. TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response. Cell Rep. 2022;39:110937 pubmed publisher
Zhang L, Tang S, Ma Y, Liu J, Monnier P, Li H, et al. RGMa Participates in the Blood-Brain Barrier Dysfunction Through BMP/BMPR/YAP Signaling in Multiple Sclerosis. Front Immunol. 2022;13:861486 pubmed publisher
Sorin S, Kubota S, Hamidi S, Yokomizo Nakano T, Vaeteewoottacharn K, Wongkham S, et al. HMGN3 represses transcription of epithelial regulators to promote migration of cholangiocarcinoma in a SNAI2-dependent manner. FASEB J. 2022;36:e22345 pubmed publisher
Branca J, Carrino D, Paternostro F, Morucci G, Fiorillo C, Nicoletti C, et al. The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model. Cells. 2022;11: pubmed publisher
Wang W, Su L, Wang Y, Li C, Ji F, Jiao J. Endothelial Cells Mediated by UCP2 Control the Neurogenic-to-Astrogenic Neural Stem Cells Fate Switch During Brain Development. Adv Sci (Weinh). 2022;9:e2105208 pubmed publisher
Ayloo S, Lazo C, Sun S, Zhang W, Cui B, Gu C. Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier. Neuron. 2022;110:1641-1655.e6 pubmed publisher
Lindenau K, Barr J, Higgins C, Sporici K, Brailoiu E, Brailoiu G. Blood-Brain Barrier Disruption Mediated by FFA1 Receptor-Evidence Using Miniscope. Int J Mol Sci. 2022;23: pubmed publisher
Sivakumar S, Qi S, Cheng N, Sathe A, Kanchwala M, Kumar A, et al. TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Cell Rep. 2022;38:110395 pubmed publisher
Yue Q, Zhou X, Zhang Z, Hoi M. Murine Beta-Amyloid (1-42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors. Int J Mol Sci. 2022;23: pubmed publisher
Rofaani E, Huang B, Liang F, Peng J, Chen Y. Reconstituted basement membrane enables airway epithelium modeling and nanoparticle toxicity testing. Int J Biol Macromol. 2022;204:300-309 pubmed publisher
Bordoni V, Matusali G, Mariotti D, Antonioli M, Cimini E, Sacchi A, et al. The interplay between SARS-CoV-2 infected airway epithelium and immune cells modulates regulatory/inflammatory signals. iScience. 2022;25:103854 pubmed publisher
Landowski M, Bhute V, Takimoto T, Grindel S, Shahi P, Pattnaik B, et al. A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups. Sci Rep. 2022;12:756 pubmed publisher
Pokharel S, Gliyazova N, Dandepally S, Williams A, Ibeanu G. Neuroprotective effects of an in vitro BBB permeable phenoxythiophene sulfonamide small molecule in glutamate-induced oxidative injury. Exp Ther Med. 2022;23:79 pubmed publisher
Salman M, Ismael S, Li L, Ahmed H, Puchowicz M, Ishrat T. Acute Hyperglycemia Exacerbates Hemorrhagic Transformation after Embolic Stroke and Reperfusion with tPA: A Possible Role of TXNIP-NLRP3 Inflammasome. J Stroke Cerebrovasc Dis. 2022;31:106226 pubmed publisher
Yang Z, Huang C, Wen X, Liu W, Huang X, Li Y, et al. Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion. Mol Ther. 2022;30:1275-1287 pubmed publisher
Montagne A, Nikolakopoulou A, Huuskonen M, Sagare A, Lawson E, Lazic D, et al. APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β. Nat Aging. 2021;1:506-520 pubmed publisher
Wang C, Liu J, Zhang X, Chen Q, Bai X, Hong X, et al. Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury. Front Pharmacol. 2021;12:784489 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
ZO-1 Polyclonal Antibody
Catalog # :
40-2200
Quantity :
100 µg
Price :
US 520.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Canine, Human, Mouse, Rat
Applications :
Immunocytochemistry: 2.5-5 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent
Species :
Canine, Human, Mouse, Rat
Isotype :
IgG
Storage :
-20°C
Description :
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Immunogen :
Synthetic peptide in the middle region of the ZO-1 protein.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 2.5-5 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent
Aliases :
DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA