PDGF-D Polyclonal Antibody | Invitrogen 40-2100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PDGF-D Polyclonal Antibody

catalog :

40-2100

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 5

Reference
Li Z, Yu S, Liu Y, Hu X, Li Y, Xiao Z, et al. SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway. J Neuroinflammation. 2022;19:95 pubmed publisher
Cheng Y, Zhang Z, Lan B, Lin J, Chen X, Kong L, et al. PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice. J Exp Med. 2021;218: pubmed publisher
Krenzlin H, Behera P, Lorenz V, Passaro C, Zdioruk M, Nowicki M, et al. Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis. J Clin Invest. 2019;130:1671-1683 pubmed publisher
Komatsubara T, Oshiro H, Sakuma Y, Sata N, Niki T, Fukushima N. Overexpression of matriptase in tumor stroma is a poor prognostic indicator of extrahepatic bile duct cancer. Pathol Int. 2019;69:86-93 pubmed publisher
Lee Y, Ke C, Tien N, Lin P. Hyperhomocysteinemia Causes Chorioretinal Angiogenesis with Placental Growth Factor Upregulation. Sci Rep. 2018;8:15755 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PDGF-D Polyclonal Antibody

Catalog # :

40-2100

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:50, Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

The platelet-derived growth factor (PDGF) family consists of four members; PDGF-A, PDGF-B, PDGF-C and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). PDGF members form disulphide-bonded dimeric isoforms, which are important for growth, survival and function in several types of connective tissue cells. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-a and PDGFR-b, and PDGF-mediated signaling is critical for development of many organ systems. PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. PDGF-D induces cellular transformation and promotes tumor growth by accelerating the proliferation rate of tumor cells and by stimulation of tumor neovascularization. PDGF-D may play a role in the development of brain tumors. The potential oncogenic activity of PDGF-DD may be important for the development and/or progression of prostate cancer. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells and in a variety of tumor cell lines including those derived from ovarian, renal and lung cancers, as well as from astrocytomas and medulloblastomas. PDGF-D is expressed in the human kidney.

Immunogen :

Synthetic peptide derived from the C-terminal region of the human PDGF-D

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50, Western Blot: Assay-dependent

Aliases :

1110003I09Rik; Iegf; Iris-expressed growth factor; MSTP036; Pdgfd; PDGF-D; PDGFD latent form; PDGFD receptor-binding form; platelet derived growth factor D; platelet-derived growth factor D; Platelet-derived growth factor D, latent form; Platelet-derived growth factor D, receptor-binding form; platelet-derived growth factor, D polypeptide; rSCDGF-B; SCDGFB; SCDGF-B; spinal cord derived growth factor B; spinal cord-derived growth factor B; spinal cord-derived growth factor-B; spinal-cord derived growth factor-B protein; UNQ1899/PRO4345