Thrombospondin 1 Monoclonal Antibody (A6.1) | Invitrogen 39-9300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Thrombospondin 1 Monoclonal Antibody (A6.1)

catalog :

39-9300

quantity :

100 µg

price :

US 430

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A6.1

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; fig 1 immunocytochemistry; mouse; fig 2	Labrousse Arias D, Castillo GonzÃ¡lez R, Rogers N, Torres Capelli M, Barreira B, AragonÃ©s J, et al. HIF-2Î±-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction. Cardiovasc Res. 2016;109:115-30 pubmed publisher
western blot; human; 1:1000; fig 6b	Lee I, Koo K, Jung K, Kim M, Kim I, Hwang K, et al. Neurogenin-2-transduced human neural progenitor cells attenuate neonatal hypoxic-ischemic brain injury. Transl Res. 2017;183:121-136.e9 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100; fig 2	Kuroki H, Hayashi H, Nakagawa S, Sakamoto K, Higashi T, Nitta H, et al. Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor Î² signal activation and liver regeneration after hepatectomy in an experimental model. Br J Surg. 2015;102:813-25 pubmed publisher
western blot; mouse	Fei P, Zaitoun I, Farnoodian M, Fisk D, Wang S, Sorenson C, et al. Expression of thrombospondin-1 modulates the angioinflammatory phenotype of choroidal endothelial cells. PLoS ONE. 2014;9:e116423 pubmed publisher
western blot; mouse	Shin E, Huang Q, Gurel Z, Sorenson C, Sheibani N. High glucose alters retinal astrocytes phenotype through increased production of inflammatory cytokines and oxidative stress. PLoS ONE. 2014;9:e103148 pubmed publisher
western blot; mouse	Shin E, Sorenson C, Sheibani N. PEDF expression regulates the proangiogenic and proinflammatory phenotype of the lung endothelium. Am J Physiol Lung Cell Mol Physiol. 2014;306:L620-34 pubmed publisher
western blot; mouse	Morrison M, Palenski T, Jamali N, Sheibani N, Sorenson C. Modulation of vascular cell function by bim expression. Int J Cell Biol. 2013;2013:297537 pubmed publisher
western blot; mouse; 1:1,000	Zhao Y, Wang S, Sorenson C, Teixeira L, Dubielzig R, Peters D, et al. Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress. Mol Cell Biol. 2013;33:4225-40 pubmed publisher
western blot; mouse; 1:1000	Audet G, Fulks D, Stricker J, Olfert I. Chronic delivery of a thrombospondin-1 mimetic decreases skeletal muscle capillarity in mice. PLoS ONE. 2013;8:e55953 pubmed publisher
western blot; mouse; fig 4	Grutzmacher C, Park S, Zhao Y, Morrison M, Sheibani N, Sorenson C. Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes. Am J Physiol Renal Physiol. 2013;304:F19-30 pubmed publisher
western blot; human; fig 4	Gouzi F, Prefaut C, Abdellaoui A, Roudier E, de Rigal P, Molinari N, et al. Blunted muscle angiogenic training-response in COPD patients versus sedentary controls. Eur Respir J. 2013;41:806-14 pubmed publisher
western blot; rat; 1:500; fig 4	Roudier E, Gineste C, Wazna A, Dehghan K, Desplanches D, Birot O. Angio-adaptation in unloaded skeletal muscle: new insights into an early and muscle type-specific dynamic process. J Physiol. 2010;588:4579-91 pubmed publisher
	Sun Y, Asano K, Sèdes L, Cantalupo A, Hansen J, Iyengar R, et al. Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells. JCI Insight. 2023;8: pubmed publisher
	Staverosky J, Dhamodaran K, Acott T, Raghunathan V, Vranka J. Isolation and Characterization of primary human trabecular meshwork cells from segmental flow regions: New tools for understanding segmental flow. Exp Eye Res. 2020;197:108046 pubmed publisher
	Audet G, Meek T, Garland T, Olfert I. Expression of angiogenic regulators and skeletal muscle capillarity in selectively bred high aerobic capacity mice. Exp Physiol. 2011;96:1138-50 pubmed publisher
	Ali N, Gaughan A, Orosz C, Baran C, McMaken S, Wang Y, et al. Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1. PLoS ONE. 2008;3:e1914 pubmed publisher
	Tenan M, Fulci G, Albertoni M, Diserens A, Hamou M, El Atifi Borel M, et al. Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells. J Exp Med. 2000;191:1789-98 pubmed
	Koch A, Friedman J, Burrows J, Haines G, Bouck N. Localization of the angiogenesis inhibitor thrombospondin in human synovial tissues. Pathobiology. 1993;61:1-6 pubmed

product information

Product Type :

Antibody

Product Name :

Thrombospondin 1 Monoclonal Antibody (A6.1)

Catalog # :

39-9300

Quantity :

100 µg

Price :

US 430

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Inhibition Assays: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

A6.1

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

Immunogen :

Full-length purified human, mouse, and rat hrombospondin 1 derived from the supernatant of thrombin-activated platelets

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Inhibition Assays: Assay-dependent, Western Blot: Assay-dependent

Aliases :

glycoprotein G; tbsp1; THBS; Thbs1; Thbs-1; thrombospondin; thrombospondin 1; thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1; TSP; TSP1; TSP-1

more info or order :

Invitrogen product webpage