IRF8 Monoclonal Antibody (ZI003) | Invitrogen 39-8800 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IRF8 Monoclonal Antibody (ZI003)

catalog :

39-8800

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ZI003

reactivity :

human, mouse

application :

western blot, ELISA

citations: 3

Reference
Caviness P, Gai D, Lazarenko O, Blackburn M, Zhan F, Chen J. Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model. FASEB J. 2023;37:e23019 pubmed publisher
Das A, Wang X, Kang J, Coulter A, Shetty A, Bachu M, et al. Monocyte Subsets With High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8. J Bone Miner Res. 2021;36:199-214 pubmed publisher
Gaillard C, Surianarayanan S, Bentley T, Warr M, Fitch B, Geng H, et al. Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia. Blood Adv. 2018;2:2462-2466 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IRF8 Monoclonal Antibody (ZI003)

Catalog # :

39-8800

Quantity :

100 ug

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Western Blot: 2 ug/mL

Species :

Human, Mouse

Clone :

ZI003

Isotype :

IgG1, kappa

Storage :

-20 C

Description :

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

Immunogen :

Synthetic peptide derived from the C-terminal region of the human ICSBP protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: 2 ug/mL

Aliases :

AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP