MINA53 Monoclonal Antibody (M532) | Invitrogen 39-7300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MINA53 Monoclonal Antibody (M532)

catalog :

39-7300

quantity :

100 µg

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M532

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; loading ...; fig 1a	Zhang Q, Wadgaonkar P, Xu L, Thakur C, Fu Y, Bi Z, et al. Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism. Theranostics. 2021;11:7970-7983 pubmed publisher
western blot; human; fig 5	Lian S, Potula H, Pillai M, Van Stry M, Koyanagi M, Chung L, et al. Transcriptional activation of Mina by Sp1/3 factors. PLoS ONE. 2013;8:e80638 pubmed publisher
chromatin immunoprecipitation; mouse; 2 ug/ml western blot; mouse	Okamoto M, Van Stry M, Chung L, Koyanagi M, Sun X, Suzuki Y, et al. Mina, an Il4 repressor, controls T helper type 2 bias. Nat Immunol. 2009;10:872-9 pubmed publisher
	Zhang Q, Fu Y, Thakur C, Bi Z, Wadgaonkar P, Qiu Y, et al. CRISPR-Cas9 gene editing causes alternative splicing of the targeting mRNA. Biochem Biophys Res Commun. 2020;528:54-61 pubmed publisher
	Zhang L, Huo Q, Ge C, Zhao F, Zhou Q, Chen X, et al. ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma. Cancer Res. 2020;80:2599-2611 pubmed publisher
	Xuan F, Huang M, Zhao E, Cui H. MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response. Cell Death Dis. 2018;9:1062 pubmed publisher
	Teye K, Tsuneoka M, Arima N, Koda Y, Nakamura Y, Ueta Y, et al. Increased expression of a Myc target gene Mina53 in human colon cancer. Am J Pathol. 2004;164:205-16 pubmed

product information

Product Type :

Antibody

Product Name :

MINA53 Monoclonal Antibody (M532)

Catalog # :

39-7300

Quantity :

100 µg

Price :

US 450

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunohistochemistry: Assay-dependent, Western Blot: 1-3 µg/mL

Species :

Human

Clone :

M532

Isotype :

IgG2a, kappa

Storage :

-20°C

Description :

MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.

Immunogen :

Recombinant full-length human Mina53

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunohistochemistry: Assay-dependent, Western Blot: 1-3 µg/mL

Aliases :

1810047J07Rik; 2410057H13Rik; 3830408E23Rik; 60S ribosomal protein L27a histidine hydroxylase; AI449204; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; histone lysine demethylase MINA; MDIG; mina; mina {ECO:0000312; Mina53; Mina-53; mineral dust induced gene protein; mineral dust-induced gene protein; MYC induced nuclear antigen; myc-induced nuclear antigen; myc-induced nuclear antigen, 53 kDa; NO52; Nucleolar protein 52; Protein mina53; RGD:708521}; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; RIOX2; ROX

more info or order :

Invitrogen product webpage