PIAS1 Monoclonal Antibody (ZP008) | Invitrogen 39-6600 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PIAS1 Monoclonal Antibody (ZP008)

catalog :

39-6600

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ZP008

reactivity :

human, mouse

application :

western blot, ELISA

citations: 2

Reference
Ochaba J, Monteys A, O Rourke J, Reidling J, Steffan J, Davidson B, et al. PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo. Neuron. 2016;90:507-20 pubmed publisher
Du J, Yun C, Bialkowska A, Yang V. Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5. J Biol Chem. 2007;282:4782-93 pubmed

product information

Product Type :

Antibody

Product Name :

PIAS1 Monoclonal Antibody (ZP008)

Catalog # :

39-6600

Quantity :

100 ug

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Western Blot: 1-3 ug/mL

Species :

Human, Mouse

Clone :

ZP008

Isotype :

IgG1, kappa

Storage :

-20 C

Description :

PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.

Immunogen :

Recombinant protein derived from the internal region of the human PIAS1 protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: 1-3 ug/mL

Aliases :

2900068C24Rik; AR interacting protein; Ddxbp1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; GBP; Gu binding protein; GU/RH-II; gu-binding protein; PIAS1; protein inhibitor of activated STAT 1; protein inhibitor of activated STAT protein 1; protein inhibitor of activated STAT, 1; protein inhibitor of activated STAT-1; RING-type E3 ubiquitin transferase PIAS1; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; ZMIZ3