PODXL Monoclonal Antibody (3D3) | Invitrogen 39-3800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PODXL Monoclonal Antibody (3D3)

catalog :

39-3800

quantity :

100 µg

price :

US 500.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D3

reactivity :

human, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; dogs; 1:100; loading ...; fig 1c	Raya Sandino A, Castillo Kauil A, Domínguez Calderón A, Alarcón L, Flores Benitez D, Cuellar Perez F, et al. Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function. Biochim Biophys Acta Mol Cell Res. 2017;1864:1714-1733 pubmed publisher
immunocytochemistry; human; 1:50; loading ...; fig 1a	Fall B, Scott C, Mauer M, Shankland S, Pippin J, Jefferson J, et al. Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy. PLoS ONE. 2016;11:e0168346 pubmed publisher
immunocytochemistry; human; 1:500; fig 1	Huang Z, Huang Y, He H, Ni J. Podocalyxin promotes cisplatin chemoresistance in osteosarcoma cells through phosphatidylinositide 3-kinase signaling. Mol Med Rep. 2015;12:3916-3922 pubmed publisher
western blot; human	Zhou Y, Zhang L, Pan H, Wang B, Yan F, Fang X, et al. Bmi1 essentially mediates podocalyxin-enhanced Cisplatin chemoresistance in oral tongue squamous cell carcinoma. PLoS ONE. 2015;10:e0123208 pubmed publisher
western blot; human; fig 1	Liu B, Liu Y, Jiang Y. Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation by inhibiting angiotensin-(1-7)/Mas signaling. Oncol Rep. 2015;33:2583-91 pubmed publisher
western blot; human; 1:1000	Liu Y, Yang L, Liu B, Jiang Y. Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation via Î²-catenin signaling. PLoS ONE. 2014;9:e111343 pubmed publisher
western blot; human; 1:10,000	Jiang J, Liu Y, Fang W, Liu F. Sperm?associated antigen 9 promotes astrocytoma cell invasion through the upregulation of podocalyxin. Mol Med Rep. 2014;10:417-22 pubmed publisher
immunohistochemistry; human; 1:500; fig 1 western blot; human; fig 3	Okatsu K, Uno M, Koyano F, Go E, Kimura M, Oka T, et al. A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment. J Biol Chem. 2013;288:36372-84 pubmed publisher
western blot; human; 1:10,000; fig 1	Wu H, Yang L, Liao D, Chen Y, Wang W, Fang J. Podocalyxin regulates astrocytoma cell invasion and survival against temozolomide. Exp Ther Med. 2013;5:1025-1029 pubmed
western blot; human; fig 7	Wang D, Li Y, Wu C, Liu Y. PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression. PLoS ONE. 2011;6:e17048 pubmed publisher
	Tuffin J, Chesor M, Kuzmuk V, Johnson T, Satchell S, Welsh G, et al. GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening. Commun Biol. 2021;4:1351 pubmed publisher
	Hale L, Howden S, Phipson B, Lonsdale A, Er P, Ghobrial I, et al. 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening. Nat Commun. 2018;9:5167 pubmed publisher
	Petrica L, Ursoniu S, Gadalean F, Vlad A, Gluhovschi G, Dumitrascu V, et al. Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus. Diabetol Metab Syndr. 2017;9:31 pubmed publisher
	Vlad A, Vlad M, Petrica L, Ursoniu S, Gadalean F, Popescu R, et al. Therapy with atorvastatin versus rosuvastatin reduces urinary podocytes, podocyte-associated molecules, and proximal tubule dysfunction biomarkers in patients with type 2 diabetes mellitus: a pilot study. Ren Fail. 2017;39:112-119 pubmed publisher
	Huang T, Jin X, He L, Zhang M, Wu J, Wang Y, et al. Role of podocalyxin in astrocytoma: Clinicopathological and in vitro evidence. Oncol Lett. 2013;6:1390-1396 pubmed
	Konii H, Sato K, Kikuchi S, Okiyama H, Watanabe R, Hasegawa A, et al. Stimulatory effects of cardiotrophin 1 on atherosclerosis. Hypertension. 2013;62:942-50 pubmed publisher
	Somasiri A, Nielsen J, Makretsov N, McCoy M, Prentice L, Gilks C, et al. Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression. Cancer Res. 2004;64:5068-73 pubmed
	Economou C, Kitsiou P, Tzinia A, Panagopoulou E, Marinos E, Kershaw D, et al. Enhanced podocalyxin expression alters the structure of podocyte basal surface. J Cell Sci. 2004;117:3281-94 pubmed
	Schopperle W, Kershaw D, DeWolf W. Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin. Biochem Biophys Res Commun. 2003;300:285-90 pubmed

product information

Product Type :

Antibody

Product Name :

PODXL Monoclonal Antibody (3D3)

Catalog # :

39-3800

Quantity :

100 µg

Price :

US 500.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 1:2,000, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 2 µg/mL

Species :

Human

Clone :

3D3

Isotype :

IgG1

Storage :

-20°C

Description :

This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.

Immunogen :

Human podocalyxin fusion protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:2,000, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 2 µg/mL

Aliases :

AW121214; GCTM-2 antigen; Gp200; Ly102; MGC138240; PC; PCLP; PCLP antibody; Pclp1; PCLP-1; PCLP1 antibody; PODLX2; podocalyxin; podocalyxin like; podocalyxin-like; podocalyxin-like protein 1; podolyxin; Podxl

more info or order :

Invitrogen product webpage