alpha Synuclein Monoclonal Antibody (n847) | Invitrogen 39-1800 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

alpha Synuclein Monoclonal Antibody (n847)

catalog :

39-1800

quantity :

100µg

price :

US 331.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

n847

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 1

Reference
Horiguchi T, Uryu K, Giasson B, Ischiropoulos H, Lightfoot R, Bellmann C, et al. Nitration of tau protein is linked to neurodegeneration in tauopathies. Am J Pathol. 2003;163:1021-31 pubmed

product information

Product Type :

Antibody

Product Name :

alpha Synuclein Monoclonal Antibody (n847)

Catalog # :

39-1800

Quantity :

100µg

Price :

US 331.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Rat

Applications :

Immunofluorescence: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent

Species :

Human, Rat

Clone :

n847

Isotype :

IgG1

Storage :

-20°C

Description :

Alpha-Synuclein belongs to the Synuclein family, which includes beta and gamma Synuclein, and is predominantly expressed in neurons, and concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. Alpha-Synuclein is involved in the formation of SNARE complexes, and most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1. The alpha and beta synucleins are found primarily in brain tissue where they are seen mainly in neuronal cytosol and presynaptic terminals. The antibody specific for alpha-synuclein does not cross react with beta-synuclein and will be useful for the confirmation of Parkinson's disease and Lewy body dementia and other studies for the localization and detection of alpha-synuclein. Four alternatively spliced transcripts that encode two different isoforms of the alpha-synuclein protein have been identified.

Immunogen :

Nitrated recombinant human alpha-Synuclein

Format :

Liquid

Applications w/Dilutions :

Immunofluorescence: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent

Aliases :

NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, SYN, SYUA, alpha-synuclein, synuclein, alpha