HuR Monoclonal Antibody (3A2) | Invitrogen 39-0600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HuR Monoclonal Antibody (3A2)

catalog :

39-0600

quantity :

100 µg

price :

US 500

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A2

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, RNA immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot; human	Weng K, Hung C, Hsieh P, Li M, Chen G, Kung Y, et al. A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells. Nucleic Acids Res. 2014;42:12789-805 pubmed publisher
immunocytochemistry; mouse; fig 2	Walker A, Soo K, Sundaramoorthy V, Parakh S, Ma Y, Farg M, et al. ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation. PLoS ONE. 2013;8:e81170 pubmed publisher
immunohistochemistry; human	Hackman P, Sarparanta J, Lehtinen S, Vihola A, EvilÃ¤ A, Jonson P, et al. Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1. Ann Neurol. 2013;73:500-9 pubmed publisher
immunocytochemistry; human; fig 4 western blot; human; fig 2	Markus M, Marques F, Morris B. Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs. PLoS ONE. 2011;6:e28926 pubmed publisher
immunoprecipitation; human; fig 2 western blot; human; fig 2	Chock K, Allison J, ElShamy W. BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells. Oncogene. 2010;29:5274-85 pubmed publisher
	G xe9 labert C, Papoutsoglou P, Gol xe1 n I, Ahlstr xf6 m E, Ameur A, Heldin C, et al. The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion. Cell Commun Signal. 2023;21:271 pubmed publisher
	Bougras Cartron G, Nadaradjane A, Joalland M, Lalier Bretaudeau L, Raimbourg J, Cartron P. Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression. Cancers (Basel). 2023;15: pubmed publisher
	Shi B, Zhang J, Heng J, Gong J, Zhang T, Li P, et al. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Genome Biol. 2020;21:120 pubmed publisher
	Dai P, Wang X, Gou L, Li Z, Wen Z, Chen Z, et al. A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis. Cell. 2019;179:1566-1581.e16 pubmed publisher
	Dhir T, Schultz C, Jain A, Brown S, Haber A, Goetz A, et al. Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition. Mol Cancer Res. 2019;17:2029-2041 pubmed publisher
	Zagore L, Sweet T, Hannigan M, Weyn Vanhentenryck S, Jobava R, Hatzoglou M, et al. DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions. Cell Rep. 2018;25:1225-1240.e6 pubmed publisher
	Soo K, Sultana J, King A, Atkinson R, Warraich S, Sundaramoorthy V, et al. ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1. Cell Death Discov. 2015;1:15030 pubmed publisher
	Kim G, Lim S, Kim Y. Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. Mod Pathol. 2011;24:1336-47 pubmed publisher
	Tiruchinapalli D, Caron M, Keene J. Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. J Neurochem. 2008;107:1529-43 pubmed publisher
	Denkert C, Weichert W, Pest S, Koch I, Licht D, Köbel M, et al. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. Cancer Res. 2004;64:189-95 pubmed
	Gallouzi I, Brennan C, Stenberg M, Swanson M, Eversole A, Maizels N, et al. HuR binding to cytoplasmic mRNA is perturbed by heat shock. Proc Natl Acad Sci U S A. 2000;97:3073-8 pubmed

product information

Product Type :

Antibody

Product Name :

HuR Monoclonal Antibody (3A2)

Catalog # :

39-0600

Quantity :

100 µg

Price :

US 500

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:250, Immunohistochemistry: Assay-dependent, RNA Immunoprecipitation: 5 µL/10^6 ceLLs, Western Blot: 1-3 µg/mL

Species :

Human

Clone :

3A2

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.

Immunogen :

Recombinant human HuR protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:250, Immunohistochemistry: Assay-dependent, RNA Immunoprecipitation: 5 µL/10^6 ceLLs, Western Blot: 1-3 µg/mL

Aliases :

2410055N02Rik; ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R); ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like 1; ELAV like RNA binding protein 1; ELAV like RNA binding protein 1a; ELAV1; Elavl1; elavl1 protein; elavl1a; elav-like generic protein; ELAV-like protein 1; ELAV-like protein 1; ELAV-like protein 1a; elav-related A; Elra; embryonic lethal, abnormal vision, drosophila, homolog-like 1; embryonic lethal, abnormal vision-related A; etID309757.2; fa25f08; fb59a02; fc60g02; Hu antigen R; Hua; HU-antigen A; hu-antigen R; Human antigen R; HuR; melG; ribonucleoprotein; W91709; wu:fa25f08; wu:fb59a02; wu:fc60g02; zHuA

more info or order :

Invitrogen product webpage