ZO-2 Polyclonal Antibody | Invitrogen 38-9100 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZO-2 Polyclonal Antibody

catalog :

38-9100

quantity :

100 µg

price :

US 449.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs

application :

western blot, immunocytochemistry, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; rat; loading ...; fig 4d	Van Itallie C, Tietgens A, Anderson J. Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1. Mol Biol Cell. 2017;28:524-534 pubmed publisher
	Yang Y, Fan X, Ji Y, Li J, Dai Z, Wu Z. Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling. Anim Nutr. 2022;8:1-9 pubmed publisher
	Sugawara T, Furuse K, Otani T, Wakayama T, Furuse M. Angulin-1 seals tricellular contacts independently of tricellulin and claudins. J Cell Biol. 2021;220: pubmed publisher
	Banerjee M, Li Z, Gao Y, Lai F, Huang M, Zhang Z, et al. Inverse agonism at the Na/K-ATPase receptor reverses EMT in prostate cancer cells. Prostate. 2021;81:667-682 pubmed publisher
	Jia H, Zhang Y, Si X, Jin Y, Jiang D, Dai Z, et al. Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes. Nutrients. 2021;13: pubmed publisher
	Zhou X, Brown B, Siegel A, El Masry M, Zeng X, Song W, et al. Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing. ACS Nano. 2020;14:12732-12748 pubmed publisher
	Otani T, Nguyen T, Tokuda S, Sugihara K, Sugawara T, Furuse K, et al. Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. J Cell Biol. 2019;218:3372-3396 pubmed publisher
	Nierwińska K, Nowacka Chmielewska M, Bernacki J, Jagsz S, Chalimoniuk M, Langfort J, et al. The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats. PLoS ONE. 2019;14:e0211818 pubmed publisher
	Van Itallie C, Tietgens A, Aponte A, Gucek M, Cartagena Rivera A, Chadwick R, et al. MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells. J Cell Sci. 2018;131: pubmed publisher
	Cartagena Rivera A, Van Itallie C, Anderson J, Chadwick R. Apical surface supracellular mechanical properties in polarized epithelium using noninvasive acoustic force spectroscopy. Nat Commun. 2017;8:1030 pubmed publisher
	Ahmed N, Ghatak S, El Masry M, Gnyawali S, Roy S, Amer M, et al. Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling. Mol Ther. 2017;25:2502-2512 pubmed publisher
	Yu H, Xue Y, Wang P, Liu X, Ma J, Zheng J, et al. Knockdown of long non-coding RNA XIST increases blood-tumor barrier permeability and inhibits glioma angiogenesis by targeting miR-137. Oncogenesis. 2017;6:e303 pubmed publisher
	Van Itallie C, Tietgens A, Krystofiak E, Kachar B, Anderson J. A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction. Mol Biol Cell. 2015;26:2769-87 pubmed publisher
	Tokuda S, Furuse M. Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells. PLoS ONE. 2015;10:e0119869 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ZO-2 Polyclonal Antibody

Catalog # :

38-9100

Quantity :

100 µg

Price :

US 449.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Canine, Human, Mouse, Rat

Applications :

Immunocytochemistry: 1-2 µg/mL, Western Blot: 1-3 µg/mL

Species :

Canine, Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.

Immunogen :

Synthetic peptide derived from the C-terminal region of human or dog ZO-2

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1-2 µg/mL, Western Blot: 1-3 µg/mL

Aliases :

C9DUPq21.11; DFNA51; DUP9q21.11; Friedreich ataxia region gene X104 (tight junction protein ZO-2); PFIC4; tight junction protein; tight junction protein 2; tight junction protein 2 (zona occludens 2); tight junction protein ZO-2; Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2); Tjp2; X104; ZO2; ZO-2; zona occludens 2; zona occludens protein 2; Zonula occludens protein 2

more info or order :

Invitrogen product webpage