Claudin 18 Polyclonal Antibody | Invitrogen 38-8000 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Claudin 18 Polyclonal Antibody

catalog :

38-8000

quantity :

100 µg

price :

US 430

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:100; loading ...; tbl 1 immunoprecipitation; mouse; 1:100; loading ...; tbl 1	Barth K, Blasche R, Neiser A, Bramke S, Frank J, Kasper M. P2X7R-dependent regulation of glycogen synthase kinase 3β and claudin-18 in alveolar epithelial type I cells of mice lung. Histochem Cell Biol. 2016;146:757-768 pubmed publisher
	Lynn K, Easley K, Martinez F, Reed R, Schlingmann B, Koval M. Asymmetric distribution of dynamin-2 and β-catenin relative to tight junction spikes in alveolar epithelial cells. Tissue Barriers. 2021;9:1929786 pubmed publisher
	Katsuya N, Sentani K, Sekino Y, Yamamoto Y, Kobayashi G, Babasaki T, et al. Clinicopathological significance of intelectin-1 in colorectal cancer: Intelectin-1 participates in tumor suppression and favorable progress. Pathol Int. 2020;70:943-952 pubmed publisher
	Espinoza J, Riquelme I, Sagredo E, Rosa L, Garcia P, Bizama C, et al. Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma. Histopathology. 2019;74:597-607 pubmed publisher
	Tanaka A, Ishikawa S, Ushiku T, Yamazawa S, Katoh H, Hayashi A, et al. Frequent CLDN18-ARHGAP fusion in highly metastatic diffuse-type gastric cancer with relatively early onset. Oncotarget. 2018;9:29336-29350 pubmed publisher
	Balbinot C, Armant O, Elarouci N, Marisa L, Martin E, De Clara E, et al. The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. J Exp Med. 2018;215:911-926 pubmed publisher
	Wolf L, Herr C, Niederstraßer J, Beisswenger C, Bals R. Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke. PLoS ONE. 2017;12:e0180092 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Claudin 18 Polyclonal Antibody

Catalog # :

38-8000

Quantity :

100 µg

Price :

US 430

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: Assay-dependent

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20°C

Description :

Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.

Immunogen :

Synthetic peptide derived from the C-terminal region of the human Claudin-18 protein, which differs from mouse by 4 conservative amino acid replacements and one non-conservative amino acid replacement

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: Assay-dependent

Aliases :

claudin 18; claudin 18-like; claudin-18; CLDN18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; UNQ778/PRO1572

more info or order :

Invitrogen product webpage