SMAD1 Polyclonal Antibody | Invitrogen 38-5400 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SMAD1 Polyclonal Antibody

catalog :

38-5400

quantity :

100 ug

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1a	Miller D, Schmierer B, Hill C. TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation. J Cell Sci. 2019;: pubmed publisher
immunohistochemistry; mouse; 1:50; loading ...; fig 6c	Morgan E, Pittman J, DeGiacomo A, Cusher D, de Bakker C, Mroszczyk K, et al. BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing. J Orthop Res. 2016;34:2096-2105 pubmed publisher
western blot; human; 1:1000; fig 7c	Cyr Depauw C, Northey J, Tabariès S, Annis M, Dong Z, Cory S, et al. Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion. Mol Cell Biol. 2016;36:1509-25 pubmed publisher
	Prabhakar A, Hu S, Tang J, Ghatpande P, Lagna G, Jiang X, et al. Essential role of the amino-terminal region of Drosha for the Microprocessor function. iScience. 2023;26:107971 pubmed publisher
	Itoh K, Ossipova O, Sokol S. Pinhead antagonizes Admp to promote notochord formation. iScience. 2021;24:102520 pubmed publisher
	Cortez M, Masrorpour F, Ivan C, Zhang J, Younes A, Lu Y, et al. Bone morphogenetic protein 7 promotes resistance to immunotherapy. Nat Commun. 2020;11:4840 pubmed publisher
	Ossipova O, Itoh K, Radu A, Ezan J, Sokol S. Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway. Development. 2020;147: pubmed publisher
	Miller D, Bloxham R, Jiang M, Gori I, Saunders R, Das D, et al. The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery. Cell Rep. 2018;25:1841-1855.e5 pubmed publisher
	Ma P, Ren B, Yang X, Sun B, Liu X, Kong Q, et al. ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus. Open Biol. 2017;7: pubmed publisher
	Stevens M, Chaturvedi P, Rankin S, MacDonald M, Jagannathan S, Yukawa M, et al. Genomic integration of Wnt/Î²-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs. Development. 2017;144:1283-1295 pubmed publisher
	Lee S, Jeong J, Oh C, Park S, Kim J, Kim H, et al. Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation. Sci Rep. 2015;5:16577 pubmed publisher
	Wang C, Kam R, Shi W, Xia Y, Chen X, Cao Y, et al. The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling. J Biol Chem. 2015;290:21925-38 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SMAD1 Polyclonal Antibody

Catalog # :

38-5400

Quantity :

100 ug

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate

Applications :

Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate

Isotype :

IgG

Storage :

-20 C

Description :

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Immunogen :

Synthetic peptide derived from an internal region of the human Smad1 protein.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000

Aliases :

AI528653; BSP1; BSP-1; dwarfin-A; Dwf-A; DWFC; hSMAD1; JV41; JV4-1; JV5-1; MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; MAD homolog1 (mothers against decapentaplegic, Drosophila); MAD, mothers against decapentaplegic homolog 1; Madh1; MADH5; MADR1; Mad-related protein 1; Mlp1; mMad1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; mothers-against-DPP-related 1; Mothers-against-DPP-related-1; MusMLP; OTTHUMP00000220456; SMAD; Smad 1; SMAD family member 1; SMAD, mothers against DPP homolog 1; Smad1; SMAD5; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1

more info or order :

Invitrogen product webpage