APH1 Polyclonal Antibody | Invitrogen 38-3600 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

APH1 Polyclonal Antibody

catalog :

38-3600

quantity :

100µg

price :

US 299.00

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:250; fig 4	Placanica L, Zhu L, Li Y. Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. PLoS ONE. 2009;4:e5088 pubmed publisher
western blot; human; 1:250; fig 3	Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim S, Zheng H, et al. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem. 2009;284:2967-77 pubmed publisher
	Nakamura P, Hsieh C, Cramer K. EphB signaling regulates target innervation in the developing and deafferented auditory brainstem. Dev Neurobiol. 2012;72:1243-55 pubmed publisher
	Tabuchi K, Chen G, Sudhof T, Shen J. Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. J Neurosci. 2009;29:7290-301 pubmed publisher

product information

Product Type :

Antibody

Product Name :

APH1 Polyclonal Antibody

Catalog # :

38-3600

Quantity :

100µg

Price :

US 299.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20°C

Description :

APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Immunogen :

Synthetic peptide derived from the C-terminal region of human Aph-1a

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Aliases :

RP4-790G17.3, 6530402N02Rik, APH-1, APH-1A, CGI-78, aph-1alpha, gamma-secretase subunit APH-1A, presenilin-stabilization factor