PGP9.5 Polyclonal Antibody | Invitrogen 38-1000 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PGP9.5 Polyclonal Antibody

catalog :

38-1000

quantity :

100 ug

price :

US 520.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

citations: 9

Reference
Balogh M, Zhang J, Gaffney C, Kalakuntla N, Nguyen N, Trinh R, et al. Sensory neuron dysfunction in orthotopic mouse models of colon cancer. J Neuroinflammation. 2022;19:204 pubmed publisher
Ragauskas T, Rysevaite Kyguoliene K, Pauziene N, Inokaitis H, Pauza D. Chemical phenotypes of intrinsic cardiac neurons in the newborn pig (Sus scrofa domesticus Erxleben, 1777). J Morphol. 2022;283:51-65 pubmed publisher
Kobayashi E, Hwang D, Bheda Malge A, Whitehurst C, Kabanov A, Kondo S, et al. Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells. Int J Mol Sci. 2019;20: pubmed publisher
Hughes F, Hirshman N, Inouye B, Jin H, Stanton E, Yun C, et al. NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. Diabetes. 2019;68:430-440 pubmed publisher
Hughes F, Sexton S, Ledig P, Yun C, Jin H, Purves J. Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide. Am J Physiol Renal Physiol. 2019;316:F113-F120 pubmed publisher
Vasamsetti S, Florentin J, Coppin E, Stiekema L, Zheng K, Nisar M, et al. Sympathetic Neuronal Activation Triggers Myeloid Progenitor Proliferation and Differentiation. Immunity. 2018;49:93-106.e7 pubmed publisher
Kobayashi E, Aga M, Kondo S, Whitehurst C, Yoshizaki T, Pagano J, et al. C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes. mSphere. 2018;3: pubmed publisher
Lütolf R, Hughes F, Inouye B, Jin H, McMains J, Pak E, et al. NLRP3/IL-1? mediates denervation during bladder outlet obstruction in rats. Neurourol Urodyn. 2017;: pubmed publisher
Jiang X, Ma T, Zhang Y, Zhang H, Yin S, Zheng W, et al. Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice. Biol Reprod. 2015;92:79 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PGP9.5 Polyclonal Antibody

Catalog # :

38-1000

Quantity :

100 ug

Price :

US 520.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: 1-3 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.

Immunogen :

Synthetic peptide derived from an internal region of the human USF-1 protein, isoforms 1 and 2, which are identical to mouse, rat, dog, and bovine isoform 1 and to mouse and dog isoform 2

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: 1-3 ug/mL

Aliases :

AW822034; C88048; epididymis luminal protein 117; epididymis secretory protein Li 53; gad; gracile axonal dystrophy; HEL-117; HEL-S-53; MGC133697 protein; NDGOA; neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; PARK5; PGP 9.5; PGP9.5; PGP95; protein gene product 9.5; R75593; ubiquitin carboxyl-terminal esterase; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase L1; ubiquitin carboxy-terminal hydrolase L1; ubiquitin C-terminal hydrolase; ubiquitin C-terminal hydrolase 1; ubiquitin C-terminal hydrolase L1; ubiquitin thioesterase L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1; UCHL; UCHL1; UCH-L1; UCHL-1