Ubiquilin 2 Monoclonal Antibody (3D5E2) | Invitrogen 37-7700 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ubiquilin 2 Monoclonal Antibody (3D5E2)

catalog :

37-7700

quantity :

100 µg

price :

US 500

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D5E2

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse western blot; mouse	Safren N, Chang L, Dziki K, Monteiro M. Signature changes in ubiquilin expression in the R6/2 mouse model of Huntington's disease. Brain Res. 2015;1597:37-46 pubmed publisher
western blot; human	Pitcher D, de Mattos Shipley K, Wang Z, Tzortzis K, Goudevenou K, Flynn H, et al. Nuclear proteasomes carry a constitutive posttranslational modification which derails SDS-PAGE (but not CTAB-PAGE). Biochim Biophys Acta. 2014;1844:2222-8 pubmed publisher
immunohistochemistry; mouse; 1:1000 western blot; mouse	Safren N, El Ayadi A, Chang L, Terrillion C, Gould T, BOEHNING D, et al. Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease. PLoS ONE. 2014;9:e87513 pubmed publisher
	McDowell I, Ayoubi R, Fotouhi M, Southern K, McPherson P, Laflamme C. The identification of high-preforming antibodies for Ubiquilin-2 for use in Western Blot, immunoprecipitation, and immunofluorescence. F1000Res. 2023;12:355 pubmed publisher
	Saxton A, Kraemer B. Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans. G3 (Bethesda). 2021;11: pubmed publisher
	Wang S, Tatman M, Monteiro M. Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD. Acta Neuropathol Commun. 2020;8:164 pubmed publisher
	Kim S, Stiles S, Feichtmeier J, Ramesh N, Zhan L, Scalf M, et al. Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS. Hum Mol Genet. 2017;: pubmed publisher
	Ford D, Monteiro M. Studies of the role of ubiquitination in the interaction of ubiquilin with the loop and carboxyl terminal regions of presenilin-2. Biochemistry. 2007;46:8827-37 pubmed
	Hiltunen M, Lu A, Thomas A, Romano D, Kim M, Jones P, et al. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006;281:32240-53 pubmed

product information

Product Type :

Antibody

Product Name :

Ubiquilin 2 Monoclonal Antibody (3D5E2)

Catalog # :

37-7700

Quantity :

100 µg

Price :

US 500

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL

Species :

Human, Mouse

Clone :

3D5E2

Isotype :

IgG2b, kappa

Storage :

-20°C

Description :

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

Immunogen :

Recombinant protein derived from an internal region of human ubiquilin.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL

Aliases :

ALS15; CHAP1; DSK2; DSK2 homolog; HRIHFB2157; N4BP4; Nedd4 binding protein 4; Plic2; Plic-2; protein linking IAP with cytoskeleton 2; RGD1563566; ubiquilin 2; ubiquilin-2; Ubiquitin-like product Chap1/Dsk2; Ubiquitin-related protein; Ubqln2

more info or order :

Invitrogen product webpage